Effects of Risperidone in Autistic Children and Young Adults: A Systematic Review and Meta-Analysis

Author(s): Brayan Jonas Mano-Sousa, Alessandra Moraes Pedrosa, Bruna Cristina Alves, José Carlos Fernandes Galduróz, Vinícius Silva Belo, Valéria Ernestânia Chaves, Joaquim Maurício Duarte-Almeida*

Journal Name: Current Neuropharmacology

Volume 19 , Issue 4 , 2021

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Graphical Abstract:


There are several studies investigating the effects of risperidone on autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of the Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as well as weight gain and waist circumference. The protocol for the present systematic review and meta-analysis was registered on the International Prospective Register of Systematic Reviews (PROSPERO). For this study, we analysed articles (2,459), selecting them according to the PICOS strategy (Population, Intervention, Comparison, Outcome, Study design). Although risperidone is effective for the treatment of lethargy and inadequate speech, concerns about the association between weight gain, waist circumference and risperidone require a need for evaluation of the risk-benefit ratio in its use. There was a significant association between weight gain, waist circumference and risperidone. In conclusion, it was possible to suggest the efficacy of risperidone for the treatment of lethargy and inadequate speech. Finally, we emphasize that the risk-benefit in its use should be evaluated (Protocol number CRD42019122316).

Keywords: Weight gain, waist circumference, aberrant behavior checklist, autism spectrum disorder, risperidone, systematic review.

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Article Details

Year: 2021
Published on: 07 April, 2021
Page: [538 - 552]
Pages: 15
DOI: 10.2174/1570159X18666200529151741
Price: $65

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