Highly Efficient Ultrasound Promoted Synthesis of 2-phenylquinoxaline in Glycerol- Water

Author(s): Mujahed Shaikh*, Devendra Wagare, Ashvini Sonone, Ayesha Durrani

Journal Name: Current Organic Synthesis

Volume 17 , Issue 6 , 2020

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Graphical Abstract:


Introduction: Quinoxalines show diversified applications in the field of medicinal chemistry.

Materials and Methods: Therefore, we have designed a highly efficient, environmentally benign and one-pot protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and 1,2-phenylenediamine under ultrasound irradiation in glycerol-water.

Results and Discussion: We observed that, although the reaction efficiently completed in all of these solvents, the use of glycerol-water with different ratios gives consistently higher yields (89–94%) and decreases reaction times.

Conclusion: The main advantages of this protocol are that it is a green method, avoids the use of toxic catalysts and volatile organic medium and the product is obtained with excellent yield.

Keywords: O-Phenylenediamine, Acetophenone, Trimethylsilyl Chloride, Glycerol, Ultrasound, N-bromosuccinimide.

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Article Details

Year: 2020
Page: [483 - 487]
Pages: 5
DOI: 10.2174/1570179417666200529121602
Price: $65

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