Title:Inulin as a Delivery Vehicle for Targeting Colon-Specific Cancer
VOLUME: 17 ISSUE: 8
Author(s):Swati Chadha, Arun Kumar*, Shambhavi Ashwini Srivastava, Tapan Behl and Rishu Ranjan
Affiliation:Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Punjab
Keywords:Inulin, polysaccharides, colon cancer, polymeric drug delivery systems, polysaccharide, dietary fiber.
Abstract:Natural polysaccharides, as well as biopolymers, are now days widely developed for targeting
colon cancer using various drug delivery systems. Currently, healing conformations are being explored
that can efficiently play a multipurpose role. Owing to the capability of extravagance colonic
diseases with the least adverse effects, biopolymers for site specific colon delivery have developed an
increased curiosity over the past decades. Inulin (INU) was explored for its probable application as an
entrapment material concerning its degradation by enzymes in the colonic microflora and its drug release
behavior in a sustained and controlled manner. INU is a polysaccharide and it consists of 2 to 1
linkage having an extensive array of beneficial uses such as a carrier for delivery of therapeutic agents
as an indicative/investigative utensil or as a dietary fiber with added well-being aids. In the main, limited
research, as well as information, is available on the delivery of therapeutic agents using inulin specifically
for colon cancer because of its capability to subsist in the stomach’s acidic medium. This exceptional
steadiness and robustness properties are exploited in numerous patterns to target drugs securely
for the management of colonic cancer, where they effectively act and kills colonic tumor cells
easily. In this review article, recent efforts and inulin-based nano-technological approaches for colon
cancer targeting are presented and discussed.
