Background: Oxidative stress is a hallmark of many diseases. A growing body of evidence suggests that hyperglycemiainduced oxidative stress plays an important role in pancreatic β-cells dysfunction and apoptosis as well as in the development and
progression of diabetic complications. Considering the vulnerability of pancreatic β-cells to oxidative damage, induction of endogenous antioxidant enzymes or exogenous antioxidant administration has been proposed to protect pancreatic β-cells from damage.
Objectives: The present review aims to provide evidence of the effect of oxidative stress and antioxidant therapies on pancreatic β-cell
function, based on in vitro and in vivo studies.
Methods: The medline and embase databases were searched to retrieve available data.
Results: Due to poor endogenous antioxidant mechanisms pancreatic β-cells are extremely sensitive to reactive oxygen species
(ROS). Many natural extracts have been tested in vitro in pancreatic β-cell lines in terms of their antioxidant and diabetes mellitus
ameliorating effects, and the majority of them have shown a dose-dependent protective role. On the other hand, there is relatively
limited evidence regarding the in vitro antioxidant effects of antidiabetic drugs on pancreatic β-cells. About in vivo studies several
natural extracts have shown beneficial effects in the setting of diabetes by decreasing blood glucose and lipid levels, increasing insulin
sensitivity, and by up-regulating intrinsic antioxidant enzyme activity. However, there is limited evidence obtained from in vivo studies regarding antidiabetic drugs.
Conclusion: Antioxidants hold promise for developing strategies aimed at the prevention or treatment of diabetes mellitus associated
with pancreatic β-cells dysfunction, as supported by in vitro and in vivo studies. However, more in vitro studies are required about