Phytochemical Analysis and Antidiabetic Potential of Armoracia Rusticana: Pharmacological and Computational Approach

Author(s): Anam Javaid, Usman Ali Ashfaq*, Zeeshan Zafar, Arina Akmal, Saman Taj, Hina Khalid

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24 , Issue 3 , 2021


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Abstract:

Aims & Objective: Armoracia rusticana has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antidiabetic potential of bioactive compounds from Armoracia rusticana.

Methods: The antidiabetic analysis revealed that Armoracia rusticana was highly active against α- glucosidase with IC50 values of 5.6 μg/ml. Furthermore, molecular docking was used to identify the active constituents against α-glucosidase, while using acarbose as a controlled drug.

Results: Upon phytochemical screening, it was found that six out of ten phytochemicals were successfully docked in the respective binding sites. The lead phytochemical was Quercetin 3-Obeta- D-xylopyranoside, which displayed a more binding score as compared to acarbose. They were subjected to analyze for drug-like properties, which further strengthen its validation.

Conclusion: It was, therefore, concluded that Armoracia rusticana might potentially be used in the amelioration of type 2 diabetes. Potential molecules identified from this study could be considered as a lead drug to cure diabetes mellitus.

Keywords: Anti-diabetic, phytochemicals, docking, alpha-glucosidase, enzyme inhibition assay, Armoracia rusticana.

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Article Details

VOLUME: 24
ISSUE: 3
Year: 2021
Published on: 26 May, 2020
Page: [465 - 471]
Pages: 7
DOI: 10.2174/1386207323666200526134512
Price: $65

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