Title:Nose to Brain Drug Delivery System: A Comprehensive Review
VOLUME: 10 ISSUE: 4
Author(s):Pankaj Kumar, Varun Garg and Neeraj Mittal*
Affiliation:Chandigarh College of Pharmacy, Chandigarh Group of Colleges, Landran, Mohali 140307, Punjab, Cadila Healthcare Limited, Medical Affairs, Ahmedabad 382421, Gujarat, Chandigarh College of Pharmacy, Chandigarh Group of Colleges, Landran, Mohali 140307, Punjab
Keywords:Blood-brain barrier, intranasal route, liposomes, microemulsion, nanoparticles, nose to brain delivery.
Abstract:Nose to brain drug delivery system is an interesting approach to deliver a drug directly in
the brain through the nose. Intranasal drug delivery is very beneficial because it avoids first-pass metabolism
and achieves a greater concentration of drugs in the central nervous system (CNS) at a low
dose. This delivery system is used for the treatment of various neurological disorders such as Parkinson's
disease, Alzheimer's disease, schizophrenia, dementia, brain cancer, etc. To treat such types of
diseases, different formulations like nanoparticles (NPs), microemulsions, in situ gel, etc. can be used
depending on the physiochemical properties of the drug. In this review, some essential characteristics
related to the delivery of nose to the brain and their possible obstacles are underlined, which include
anatomy and physiology of nose to brain delivery. This review also summarizes innovations from the
past three to five years.
