The Potential Role of Serum Exosomes in Preeclampsia

Author(s): Xuelin Gao, Lulu Shao, Xinying Ge, Long Zhang, Dexin Chen, Rongxia He*

Journal Name: Current Drug Metabolism

Volume 21 , Issue 5 , 2020

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Abstract:

Preeclampsia is a serious pregnancy-specific disease that affects about 5%-8% of pregnant women and is the main reason for the increase in maternal and perinatal mortality. Due to unknown etiology, preeclampsia is still the main cause of increased mortality in maternal and perinatal infants, which is mainly manifested by new hypertension after 20 weeks of pregnancy. As the pathogenesis has not been fully elucidated, early diagnosis and full treatment are lacking. Exosomes secreted from the placenta to the peripheral circulation may be involved in the pathogenesis of preeclampsia and can be detected from the plasma of pregnant women after 6 weeks of pregnancy. Related studies have shown that the levels of exosomes in preeclampsia have changed, and the protein and miRNA expression profiles are also different. Therefore, monitoring changes in plasma exosomes and expression profiles may provide new ideas and new perspectives for the prediction, diagnosis and treatment of preeclampsia.

Keywords: Exosomes, preeclampsia, pregnancy-specific disease, miRNA, protein, immune regulation.

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Article Details

VOLUME: 21
ISSUE: 5
Year: 2020
Page: [352 - 356]
Pages: 5
DOI: 10.2174/1389200221666200525152441
Price: $65

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