Preeclampsia is a serious pregnancy-specific disease that affects about 5%-8% of pregnant women and is
the main reason for the increase in maternal and perinatal mortality. Due to unknown etiology, preeclampsia is still
the main cause of increased mortality in maternal and perinatal infants, which is mainly manifested by new
hypertension after 20 weeks of pregnancy. As the pathogenesis has not been fully elucidated, early diagnosis and full
treatment are lacking. Exosomes secreted from the placenta to the peripheral circulation may be involved in the
pathogenesis of preeclampsia and can be detected from the plasma of pregnant women after 6 weeks of pregnancy.
Related studies have shown that the levels of exosomes in preeclampsia have changed, and the protein and miRNA
expression profiles are also different. Therefore, monitoring changes in plasma exosomes and expression profiles
may provide new ideas and new perspectives for the prediction, diagnosis and treatment of preeclampsia.
Keywords: Exosomes, preeclampsia, pregnancy-specific disease, miRNA, protein, immune regulation.
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