Recent Advances in Herbal Nanomedicines for Cancer Treatment

(E-pub Ahead of Print)

Author(s): Deepak Pradhan, Prativa Biswasroy, Amita Sahu, Dipak Kumar Sahu, Goutam Ghosh, Goutam Rath*

Journal Name: Current Molecular Pharmacology

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Abstract:

Cancer continues to be one of the deadliest diseases that adversely impacts the large population of the world. A stack of scientific documents reflects a huge number of potent plant-based anticancer drugs such as curcumin (CUR), podophyllotoxin, camptothecin (CPT), vincristine, vinblastine, paclitaxel (PTX), etc. that have been integrated into the modern practice of cancer treatment. The demand for natural products raises exponentially as they are generally considered to be safe, and devoid of critical toxic effects at the therapeutic dose when compared to their synthetic counterparts. Despite rising interest towards the potent phytoconstituents, formulation developer faces various challenges in drug development processes such as poor water solubility, low bioavailability, marginal permeability, and nonspecific drug delivery at the target site, etc. Further, adverse drug reaction and multidrug resistance are other critical issues need to be addressed. Nanomedicines owing to their unique structural and functional attributes help to fix the above challenges for improved translational outcomes. This review summarises the prospects and challenges of a nanotechnologybased drug delivery approach for the delivery of plant-based anticancer drugs.

Keywords: Herbal anticancer drugs, nanocarriers, nanoemulsions, dendrimers, carbon nanotubes, liposomes, solid lipid nanoparticles, therapeutic outcomes.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1874467213666200525010624
Price: $95

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