The stable gastric pentadecapeptide BPC 157 protects stomach cells, maintains gastric integrity against
various noxious agents such as alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs), and exerts cytoprotection/
adaptive cytoprotection/organoprotection in other epithelia, that is, skin, liver, pancreas, heart, and brain.
Especially BPC 157 counteracts gastric endothelial injury that precedes and induces damage to the gastric epithelium
and generalizes "gastric endothelial protection" to protection of the endothelium of other vessels including
thrombosis, prolonged bleeding, and thrombocytopenia. In this background, we put the importance of BPC 157 as
a possible way of securing GI safety against NSAIDs-induced gastroenteropathy since still unmet medical needs
to mitigate NSAIDs-induced cytotoxicity are urgent. Furthermore, gastrointestinal irritants such as physical or
mental stress, NSAIDs administration, surfactants destroyer such as bile acids, alcohol can lead to leaky gut syndrome
through increasing epithelial permeability. In this review article, we described the potential rescuing actions
of BPC 157 against leaky gut syndrome after NSAIDs administration for the first time.