Background: Pharmaceutical nanotechnology represents an efficient alternative for the delivery
of pharmacologically active plant-derived compounds, considering their protective capacity, oral
bioavailability and drug vectorization capacity. In this context, butters obtained from plant seeds have
emerged as promising products for the development of pharmacologically active nanostructures. They
possess a complex lipid composition, allowing the formation of different emulsion systems with solid
cores, since this mixture of different triglycerides is solid at room temperature and body temperature.
Therefore, the systematic mapping around the technological development of nanostructures produced
from plant-derived butters is potentially valuable for researchers interested in novel alternative formulations
for pharmacological therapy, with potential industrial, economic, health and societal impacts.
Methods: Systematic review was carried out by the search of scientific papers and patents deposited in
official databases concerning the development of nanostructured pharmaceutical products using plantderived
butters as starting material. The publications obtained were subjected to sorting and analysis
by applying the following inclusion/exclusion criteria.
Results: The Solid Lipid Nanoparticle (SLN) was the type of nanostructure produced in all the analyzed
scientific papers, due to the physicochemical characteristics of the lipid constituents of plantderived
butters. In this sense, 54% of the articles have reported the use of Cocoa Butter for the production
of nanostructures; 28% for Shea Butter; 6% for Cupuacu Butter, 6% for Murumuru Butter and 6%
for Bacuri Butter.
Discussion: In the technological prospection, only two patents exhibited SLN as an invention based on
cocoa butter and on shea butter, respectively. The production methods employed have included: phase
inversion temperature, microemulsion, hot high pressure homogenization, high shear homogenization
Conclusion: In light of this prospective review, the encouragement of novel studies in lipids-based
nanotechnology is evident, considering the small number of findings so far, in order to stimulate new
research involving plant-derived butters from easily cultivated fruits in tropical regions, then stimulating
the pharmaceutical development of new therapeutic alternatives using biocompatible and sustainable