Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years

Author(s): Zhencheng Lai, Jixiao He, Changxin Zhou, Huajun Zhao, Sunliang Cui*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 14 , 2021


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Abstract:

Tanshinones are an important type of natural products isolated from Salvia miltiorrhiza Bunge with various bioactivities. Tanshinone IIa, cryptotanshinone and tanshinone I are three kinds of tanshinones which have been widely investigated. Particularly, sodium tanshinone IIa sulfonate is a water-soluble derivative of tanshinone IIa and it is used in clinical in China for treating cardiovascular diseases. In recent years, there are increasing interests in the investigation of tanshinones derivatives in various diseases. This article presents a review of the anti-atherosclerotic effects, cardioprotective effects, anticancer activities, antibacterial activities and antiviral activities of tanshinones and structural modification work in recent years.

Keywords: Tanshinone, structural modification, anti-atherosclerotic effects, cardioprotective effects, anticancer activities, antibacterial activities, antiviral activities.

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Article Details

VOLUME: 28
ISSUE: 14
Year: 2021
Published on: 28 May, 2021
Page: [2807 - 2827]
Pages: 21
DOI: 10.2174/0929867327666200521124850
Price: $65

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