Aim and Objective: Methyldopa is one of the medications that is used for the treatment
of hypertension. Therefore, the determination of methyldopa in the presence of other biological
components is essential. In this work, a promising electrochemical sensor based on CoFe2O4
magnetic nanoparticles modified glassy carbon electrode (CoFe2O4/GCE) was developed for
electrochemical determination of methyldopa in the presence of uric acid. Cobalt ferrite
nanoparticles were synthesized via chemical method.
Materials and Methods: Characterizing the CoFe2O4 was investigated by field emission scanning
electron microscopy (FESEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy
(EDX), transmission electron microscope (TEM), and cyclic voltammetry techniques.
Results: Under the optimal experimental conditions, the current response of the electrochemical
sensor obtained with differential pulse voltammetry was increased linearly in the concentration
range from 1.45 to 15.1 μmol L−1 with the detection limit of 1.07 μmol L−1 for methyldopa. Also,
by using the proposed method, methyldopa and uric acid could be analyzed in a mixture
independently. The difference in peak potential for analytes is about 150 mV.
Conclusion: The present sensor was successfully applied for the determination of methyldopa in
the presence of uric acid in biological samples and the pharmaceutical samples with satisfactory