Aim and Objective: Myocardial infarction, cerebral infarction, and other diseases
caused by vascular obstruction have always jeopardized human life and health. Several reports
indicate that Rhei Radix et Rhizoma has a good clinical effect in the prevention and treatment of
cardiovascular diseases. Owing to the complexity of herbal medicine, the pharmacodynamic
mechanism of Rhei Radix et Rhizoma is still unclear. The objectives of this study were to explore
the two-way adjustment mechanism of Rhei Radix et Rhizoma and provide a new solution for the
prevention and treatment of cardiovascular disease.
Materials and Methods: This study used data mining, reverse pharmacophore matching, network
construction, GO and KEGG Analysis, and molecular docking to investigate the two-way
adjustment mechanism of Rhei Radix et Rhizoma. The methods used were based on systems
pharmacology and big data analysis technology.
Results: The results suggest that Rhei Radix et Rhizoma uses a two-way adjustment of activating
blood circulation, as well as blood coagulation in the prevention and treatment of cardiovascular
diseases. The components involved in activating blood circulation are mainly anthraquinone
components. The corresponding targets are NOS2, NOS3, CALM1, and the corresponding
pathways are calcium signaling pathway, VEGF signaling pathway, platelet activation, and the
PI3K-Akt signaling pathway. For blood coagulation, the components are mainly tannin
components; the corresponding targets are F2, F10, ELANE, and the corresponding pathways are
the neuroactive ligand-receptor interaction, complement and coagulation cascades.
Conclusion: This study indicated that Rhei Radix et Rhizoma exerts the two-way adjustment of
activating blood circulation and blood coagulation in the prevention and treatment of
cardiovascular diseases. It can make up for the side effects of the existing blood circulation drugs
for cardiovascular disease, only activating blood circulation, and the uncontrollable large-area
bleeding due to the long-term use of the drugs. This study provides a material basis for the
development of new blood-activating drugs based on natural medicine.