Several easy, efficient and convenient procedures to access indoles fused heterocyclic systems
are described in this review. These heterocyclic systems were synthesized from several cyclic or
acyclic molecules via a variety of reactions such as Diels-Alder reaction, Michael addition, Morita-
Baylis-Hillmann reaction and many other domino/Cascade approaches with high selectivity. Most of
the given protocols in this review proceed through organocatalytic pathways; however, some underwent
different catalytic and non-catalytic reactions.
Keywords: Analgesic, domino approach, indole heterocycles, multicomponent reactions, nootropic agents, organocatalysis,
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