With the rapid development of nanotechnology, various nanomaterials have been applied to
bone repair and regeneration. Due to the unique chemical, physical and mechanical properties, nanomaterials
could promote stem cells osteogenic differentiation, which has great potentials in bone tissue engineering
and exploiting nanomaterials-based bone regeneration strategies. In this review, we summarized
current nanomaterials with osteo-induction ability, which could be potentially applied to bone tissue engineering.
Meanwhile, the unique properties of these nanomaterials and their effects on stem cell osteogenic
differentiation are also discussed. Furthermore, possible signaling pathways involved in the nanomaterials-
induced cell osteogenic differentiation are also highlighted in this review.