BK Polyoma Virus Nephropathy in an Immunocompromised Host

Author(s): Faraz Khan*, Maroun El Khoury, Fahad Kouli, Aaron Han

Journal Name: New Emirates Medical Journal
An official journal of Emirates Medical Association

Volume 2 , Issue 1 , 2021


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Abstract:

Background: Post-transplant Lymphoproliferative Disorders (PTLD) are a well known late complication after solid organ transplantation, including renal transplant. Among others, graft failure due to reactivation of BK polyomavirus in the grafted kidney is also a well-recognized complication but tends to present early in the first several months after transplant.

Case: Here we present the case of PTLD Burkitt's Lymphoma (BL-PTLD) in a renal transplant patient who was successfully treated with multiagent chemo-immunotherapy but later developed BK polyomavirus nephropathy (BKVN) with graft failure only after completion of her systemic therapy for lymphoma and 7 years after the transplant. Relevant literature is reviewed.

Conclusion: In this case, reactivation and progression of BKVN were most likely associated with immunosuppression from chemo-immunotherapy for her BL–PTLD, unlike early graft failures associated with BKVN.

Keywords: PTLD, Burkitt's Lymphoma, BK polyomavirus nephropathy, Lymphoproliferative disorders, Immunosuppression, Chemoimmunotherapy.

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Article Details

VOLUME: 2
ISSUE: 1
Year: 2021
Published on: 20 May, 2020
Page: [45 - 49]
Pages: 5
DOI: 10.2174/0250688201999200520125625

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