Background: Tumor-targeted delivery by nanoparticles is a great achievement
towards the use of the highly effective drug at very low doses. The conventional development of
tumor-targeted delivery by nanoparticles is based on enhanced permeability and retention (EPR)
effect and endocytosis based on receptor-mediated are very demanding, due to the biological and
natural complications of tumors as well as the restrictions on the design of the accurate
nanoparticle delivery systems.
Methods: Different tumor environment stimuli are responsible for triggered Multistage drug
delivery systems (MSDDS) for tumor therapy and imaging. Physicochemical properties such as
size, hydrophobicity and potential transform by MSDDS because of the physiological blood
circulation different, intracellular tumor environment. This system accomplishes tumor
penetration, cellular uptake improved, discharge of drugs on accurate time, and endosomal
Results: Maximum drug delivery by MSDDS mechanism to target therapeutic cells and also
tumor tissues and sub cellular organism. Poorly soluble compounds and bioavailability issues are
facing by pharmaceutical industries are resolved by nanoparticle formulation.
Conclusion: In our review, we illustrate different types of triggered moods and stimuli of tumor
environment which help in smart multistage drug delivery systems by nanoparticles, basically a
multi-stimuli sensitive delivery system, and elaborate their function, effects, and diagnosis.