Background: Tumor-targeted delivery by nanoparticles is a great achievement towards the use of highly
effective drug at very low doses. The conventional development of tumor-targeted delivery by nanoparticles is based
on enhanced permeability and retention (EPR) effect and endocytosis based on receptor-mediated are very
demanding due to the biological and natural complications of tumors as well as the restrictions on the design of the
accurate nanoparticle delivery systems.
Methods: Different tumor environment stimuli are responsible for triggered multistage drug delivery systems
(MSDDS) for tumor therapy and imaging. Physicochemical properties, such as size, hydrophobicity and potential
transform by MSDDS because of the physiological blood circulation different, intracellular tumor environment. This
system accomplishes tumor penetration, cellular uptake improved, discharge of drugs on accurate time, and
Results: Maximum drug delivery by MSDDS mechanism to target therapeutic cells and also tumor tissues and sub
cellular organism. Poorly soluble compounds and bioavailability issues have been faced by pharmaceutical
industries, which are resolved by nanoparticle formulation.
Conclusion: In our review, we illustrate different types of triggered moods and stimuli of the tumor environment,
which help in smart multistage drug delivery systems by nanoparticles, basically a multi-stimuli sensitive delivery
system, and elaborate their function, effects, and diagnosis.