Background: The design and characteristics of alginate biomaterial have a significant role
in wound dressing and tissue regeneration. The ideal biomaterial for wound dressing must be biodegradable,
biocompatible, non-inflammatory, and non-toxic.
Objective: Wound dressing should promote the re-epithelization process and protect the wound from
further infection by creating a moist environment. The physical and mechanical nature of the alginate
biopolymer has the potential to influence the pathophysiological mechanisms in the chronic wound.
The application of this biomaterial provides ample advantages than synthetic polymers.
Methods: The wound healing process is a critical step involved in different phases. The presence of
cross-linkers, various drugs along with alginate leads to a decrease in the mechanical property of
dressing. Hence the choice of an effective material for dressing along with alginate is a very critical
decision. The therapeutic efficacy of the alginate dressing system (film, hydrogel, wafer, etc.) is influenced
by the incorporation of different materials such as bioactive agents, nanoparticles, crosslinkers,
nature of the excipients, etc.
Results: The ion exchange occurring between dressing and exudates results in the formation of a gel,
due to the presence of glucuronic acid in alginate. This gel absorbs moisture and maintains an appropriate
moist environment and actively influences the pathophysiological mechanisms of the chronic
Conclusion: This review provides detailed knowledge to researchers to work with alginate and also
knowledge about the incorporation of an appropriate material and its therapeutic efficacy in wound