Curcumin is one of the important natural compounds that is extracted from turmeric.
This compound and its derivatives have numerous biological properties, including antioxidant,
anticancer, anti-inflammatory, antimicrobial, and healing effects. Extensive research in various
fields has been conducted on turmeric as it is widely used as a food additive. The significant antifungal
activity is one of the major effects of curcumin. In this paper, recent studies on the effects
of different forms of curcumin drug on the candidiasis were systematically examined and discussed.
The data in this study were extracted from the articles and reports published in the Web
of Science, Google Scholar, PubMed, and Scopus databases. After the preliminary investigation,
relevant reports were selected and classified based on the incorporated formulation and purpose
of the study. After a systematic discussion of the data, it was found that the use of medicinal
forms based on nanoparticles can increase the absorption and target the controlled release of curcumin
with a more effective role compared to other formulations. Consequently, it can be concluded
that new methods of modern medicine can be employed to increase the efficacy of natural
pharmaceutical compounds used in the past. In this regard, the present study analyzed the effect
of curcumin against various Candida infections, using the recent data. It was found that applying
a combination of drug formulation or the formulation of curcumin and its derivatives can be an
effective strategy to overcome the medicine resistance in fungal infections, especially candidiasis.