Rationale: Linezolid (LNZ) induced Cutaneous Adverse Drug Reactions (CADRs) have
rare atypical presentation. Till date, there are very few published case reports on LNZ induced CADRs
among the multidrug-resistant patients suffering from Infective Endocarditis (MDR IE). Here,
we present a rare case report of LNZ induced CARs in a MDR IE patient.
Case Report: A 24-year-old female patient was admitted to the hospital with chief complaints of
fever (101°C) associated with rigors, chills, and shortness of breath (grade IV) for the past 4 days.
She was diagnosed with MDR IE, having a prior history of rheumatic heart disease. She was prescribed
LNZ 600mg IV BD for MDR IE, against Staphylococcus coagulase-negative. The patient
experienced flares of cutaneous reactions with multiple hyper-pigmented maculopapular lesions all
over the body after one week of LNZ therapy. Upon causality assessment, she was found to be suffering
from LNZ induced CADRs. LNZ dose was tapered gradually and discontinued. The patient
was prescribed corticosteroids along with other supportive care. Her reactions completely subsided
and infection got controlled following 1 month of therapy.
Conclusion: Healthcare professionals should be vigilant for rare CADRs, while monitoring the patients
on LNZ therapy especially in MDR patients as they are exposed to multiple drugs. Moreover,
strengthened spontaneous reporting is required for better quantification.