Title:Linezolid Induced Skin Reactions in a Multi Drug Resistant Infective Endocarditis Patient: A Rare Case
VOLUME: 15
Author(s):Asha K Rajan, Ananth Kashyap, Manik Chhabra and Muhammed Rashid*
Affiliation:Department of Pharmacy Practice, Jaya College of Pharmacy, Thiruninravur, Chennai, Tamil Nadu 602024, Department of Pharmacy Practice, Sarada Vilas College of Pharmacy, Mysuru, Karnataka 570004, Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Punjab 142001, Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Nagamangala 571448, Karnataka
Keywords: infective endocarditis, linezolid, multidrug resistant, adverse drug reaction
Abstract:Rationale: Linezolid (LNZ) induced Cutaneous Adverse Drug Reactions (CADRs) are rare
atypical presentation. Till date, there are very few published case reports on the LNZ induced
CADRs among the multidrug resistant patients suffering from Infective Endocarditis (MDR
IE). Here, we present a rare case report of LNZ induced CARs in a MDR IE patient.
Case report: A 24-year-old female patient was admitted to the hospital with chief complaints
of fever (101o
c) associated with rigors, chills, and shortness of breath (grade IV) since last 4
days. She was diagnosed with a MDR IE, having a prior history of rheumatic heart disease.
She was prescribed with tablet LNZ 600mg IV BD for MDR IE, against Staphylococcus
coagulase-negative. The patient experienced flares of cutaneous reactions with multiple hyper
pigmented maculopapular lesions all over the body after one week of LNZ therapy. Upon
causality assessment, she was suffering from LNZ induced CADRs. LNZ dose was tapered
gradually and was discontinued. Patient was prescribed with corticosteroids along with other
supportive care. Her reactions were completely subsided and infection was controlled
following 1 month of therapy.
Conclusion: Healthcare Professionals should be vigilant for the rare CADRs, while
monitoring the patients on LNZ therapy especially on MDR patients as they are exposed to
multiple drugs. Moreover, a strengthened spontaneous reporting is required for a better
quantification.
