Background: Developmental venous anomalies (DVAs) can be determined on magnetic
resonance imaging (MRI), and they may be associated with multiple sclerosis (MS) lesions.
Purpose: The objective was to evaluate the MRI findings of DVAs in the brain, to compare the prevalence
of them between MS patients and control subjects, and to investigate the correlation of
DVA-associated fluid-attenuated inversion recovery (FLAIR) hyperintensities and MRI-derived parameters
between MS patients and control subjects having DVA.
Methods: Total 160 patients with a mean age of 45 ± 16 years who underwent multiparametric
MRI including susceptibility-weighted imaging (SWI), diffusion-weighted imaging, 3D FLAIR,
and contrast-enhanced imaging were included in this retrospective study. First, the presence of
DVA was compared between the MS and control groups using the Chi-square test. Then, among
the subjects having DVA, age, gender, and MRI-derived parameters such as the signal increase of
DVA on FLAIR, location, and drainage of DVA were compared between the MS and control
groups using Chi-square test.
Results: The presence of DVA did not differ between the MS and control groups (P = 0.828). Signal
increase around DVA on FLAIR (P = 0.03) and the age of less than 45 years demonstrated a
significant correlation with MS group (P = 0.022).
Conclusion: In our study, DVAs were effectively detected using SWI and 3D contrast-enhanced
T1-weighted imaging on MRI. The signal increase of DVA was better revealed on 3D FLAIR on
MRI, and it was the only significant MRI-derived parameter in patients with MS.