Background: Along with the progress in medicine and therapies, the exploitation of anti-cancer agents
focused more on the vital signaling pathways and key biological macromolecules. With rational design and advanced
synthesis, quinoline derivatives have been utilized frequently in medicinal chemistry, especially in developing
anti-cancer drugs or candidates.
Methods: Using DOI searching, articles published before 2020 all over the world have been reviewed as comprehensively
Results: In this review, we selected the representative quinoline derivate drugs in market or clinical trials, classified
them into five major categories with detailed targets according to their main mechanisms, discussed the relationship
within the same mechanism, and generated a summative discussion with prospective expectations. For each mechanism,
the introduction of the target was presented, with the typical examples of quinoline derivate drugs.
Conclusion: This review has highlighted the quinoline drugs or candidates, suited them into corresponding targets
in their pathways, summarized and discussed. We hope that this review may help the researchers who are interested
in discovering quinoline derivate anti-cancer agents obtain considerable understanding of this specific topic.
Through the flourishing period and the vigorous strategies in clinical trials, quinoline drugs would be potential but
facing new challenges in the future.