Xanthoangelol Isolated from Angelica keiskei Roots Prevents Dextran Sulfate Sodium-treated Colitis in Mice

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Author(s): Yoshiyuki Kimura*, Kimye Baba

Journal Name: The Natural Products Journal

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Abstract:

Background: The therapeutic effects of a number of natural products on inflammatory bowel disease (IBD) have recently been examined in detail. The whole herb and roots of Angelica keiskei (Umblliferae) have traditionally been used as a diuretic, to treat gastrointestinal diseases such as gastric ulcers and diarrhea in Japan. Objectives: The present study was performed to investigate the effects of xanthoangelol, a major chalcone of Angelica keiskei roots, on diarrhea and inflammation in the large intestine of IBD model mice.

Methods: Xanthoangelol (10 & 25 mg/kg) was orally administered to mice with 3% dextran sulfate sodium (DSS)-induced colitis. Blood samples were collected during the experimental period, subjected to a full blood count test, and colonic cytokine and chemokine levels were measured.

Results: Xanthoangelol (25 mg/kg) reduced the disease activity index (DAI) of colitis. It also attenuated DSS-induced reductions in red blood cell and platelet counts as well as Hb and Ht levels. A histological examination of the colon using direct fast scarlet staining showed that xanthoangelol prevented DSS-induced mucosal ulceration and eosinophil infiltration. Xanthoangelol also reduced DSS-induced increases in colonic MCP-1, IL-1β and TNF-α levels.

Conclusions: Xanthoangelol reduced DSS-induced increases in colonic IL-1β, TNF-α, and MCP-1 levels and prevented eosinophil infiltration, which support its potential of as a treatment for IBD.

Keywords: Xanthoangelol, Dextran sulfate sodium, Inflammatory bowel disease, Interleukin 1β, Tumor necrosis factor-α, Monocyte chemoattractant protein 1, Eosinophil infiltration.

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(E-pub Ahead of Print)
DOI: 10.2174/2210315510999200515100203