Background: Parkinson’s disease is a common neurodegenerative disorder characterized
by selective loss of dopaminergic neurons in the substantia nigra pars compacta.
Introduction: The effects of alpha synuclein, parkin mutation and pharmacological agents have
been studied in the Drosophila model.
Methods: The effect of cabergoline was studied on the cognitive impairments exhibited by the
transgenic Drosophila expressing human alpha-synuclein in the neurons. The PD flies were allowed
to feed on the diet having 0.5, 1 and 1.5 μM of cabergoline.
Results and Discussion: The exposure of cabergoline not only showed a dose-dependent significant
delay in the cognitive impairments but also prevented the loss of dopaminergic neurons. Molecular
docking studies showed the positive interaction between cabergoline and alpha-synuclein.
Conclusion: The results suggest a protective effect of cabergoline against the cognitive impairments.