Background and Objective: The SOX2OT lcnRNA has been recognized as positive
regulator in transcription regulation of SOX2 gene. Recent studies have approved the dysregulation of
SOX2OT lncRNA expression patterns in some common caner types including esophageal, lung, and
breast cancer. The objective of present study was to investigate correlation between overexpression of
SOX2OT lcnRNA and susceptibility to breast cancer.
Method: SOX2OT lncRNA expression profiling in 15 breast cancer and normal tumour-adjacent
breast tissue samples was performed by using qRT-PCR. To evaluating the diagnostic potential of the
SOX2OT lncRNA we performed ROC curve analyses.
Results: The expression of SOX2OT lncRNA in patients suffering from breast cancer revealed a
significant overexpression in comparison with the healthy group (P<0.001). Significantly, the elevated
circulating SOX2OT lncRNA was found specific to breast cancer and could differentiate breast cancer
from controls with 100% of both sensitivity of and specificity. Based on the Kaplan-Meier analysis,
there were no significant correlation between SOX2OT lcnRNA expression and overall survival.
Conclusion: The results confirmed the association between breast cancer and higher SOX2OT
lncRNA expression. According to the ROC curve results, SOX2OT lcnRNA could be a new
measurable indicator of the breast cancer and a potential therapeutic target for breast cancer patients.