Background and Objective: The SOX2OT lcnRNA has been recognized as a positive
regulator in the transcription regulation of the SOX2 gene. Recent studies have approved the
dysregulation of SOX2OT lncRNA expression patterns in some common cancer types, including
esophageal, lung, and breast cancer. The objective of the present study was to investigate the
correlation between overexpression of SOX2OT lcnRNA and susceptibility to breast cancer.
Methods: SOX2OT lncRNA expression profiling in 15 breast cancer and normal tumour-adjacent
breast tissue samples was performed by using qRT-PCR. To evaluate the diagnostic potential of
the SOX2OT lncRNA, we performed ROC curve analyses.
Results: The expression of SOX2OT lncRNA in patients suffering from breast cancer revealed a
significant overexpression in comparison with the healthy group (P<0.001). Significantly, the
elevated circulating SOX2OT lncRNA was found specific to breast cancer and could differentiate
breast cancer from controls with 100% of both sensitivity and specificity. Based on the Kaplan-
Meier analysis, there was no significant correlation between SOX2OT lcnRNA expression and
Conclusion: The results confirmed the association between breast cancer and higher SOX2OT
lncRNA expression. According to the ROC curve results, SOX2OT lcnRNA could be a new
measurable indicator of the breast cancer and a potential therapeutic target for breast cancer patients.