Rationale & Objective: Rodenticide poisoning, either accidental or intentional, is very
common in rural India. The absence of a definite antidote made it a major concern with a high mortality
rate. Therefore, this study aimed to assess the effectiveness of N-Acetyl Cysteine (NAC) in
rodenticide poisoning as there are recent positive shreds of evidence on it.
Methodology: A retrospective study was conducted in a tertiary care teaching hospital on patients
admitted with rodenticide poisoning during a period of 2012-2017. The Fischer’s exact test and
relative risk were measured to analyze the outcome of treatment and risk factors, respectively.
Results: A total of 229 patients were enrolled in the study with a mean age of 30.04 ± 15.67 years.
The suicidal attack was the major (86.0%) reason for poison consumption. The survival rate was
significantly (p ≤ 0.03) higher in the NAC treatment group compared to the non-NAC group.
Moreover, the majority (93.4%) of participants did not experience any adverse effects. The mean
oral loading dose and maintenance dose was 7580.95 ± 2204.29 mg and 3694.53 ± 2322.58 mg,
respectively. Yellow Phosphorus poisoning (Relative Risk [RR] 2.888 (1.179-7.079); p=0.020) and
Time lag of ≥ 24 hours (RR 3.479 (1.137-10.645); p=0.029) were the significant risk factors for
Conclusion: NAC is shown to have a significant survival benefit with a good safety profile among
rodenticide poisoners. Further adequately powered prospective researches with more emphasis on
dosing parameters are warranted for better quantification in different settings and for clinical implementation.
Keywords: Rodenticides, poisons, N-acetylcysteine, toxicology, antidotes, efficacy.Rodenticides, poisons, N-acetylcysteine, toxicology, antidotes, efficacy.Rodenticides, poisons, N-acetylcysteine, toxicology, antidotes, efficacy.
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