Title:Green Synthesis of Substituted Dihydropyrimidin-2(1H)-one by Using Zinc Chloride /Acetic Acid Catalytic System
VOLUME: 1 ISSUE: 1
Author(s):Bapu R. Thorat*, Ankita Gurav, Bharat Dalvi, Ashwini Sawant, Vikas Lokhande and Suraj N. Mali*
Affiliation:Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Mumbai-60, Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Mumbai-60, Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Mumbai-60, Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Mumbai-60, Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Mumbai-60, Department of Pharmaceutical Sciences, Government of College of Pharmacy, Karad, Maharashtra
Keywords:Biginelli reaction, dihydropyrimidinone, lewis acid, zinc chloride, acetic acid.
Abstract:Background: Biginelli reaction is the most well-known and widely studied, multicomponent
reaction used for the direct synthesis of many biologically active 3,4-dihydropyrimidin-
2(1H)-ones and their derivatives by reacting a β-keto ester/1,3-dicarbonyl compound, an aldehyde,
and urea. It is catalyzed by different Bronsted and Lewis acids.
Methods: The catalytic effect of different metal chlorides, such as sodium, potassium, magnesium,
stannous, ferric, manganese, cupric, nickel, cobalt, and zinc, in absence and presence of acetic acid
were studied.
Results: The zinc, ferric, cupric, and cobalt chlorides were found to be more effective catalysts for
Biginelli reaction at room temperature. The yield of the reaction increased with temperature for all
catalytic systems. Acetophenone, cyclohexanone, acetyl acetone, and different β-ketoesters formed
tetrahedropyrimidine in moderate to good yield, by using zinc chloride catalyst at room
temperature in acetic acid. The efficiency of the catalyst was studied by treating different
substituted aldehydes with 1,3-dicarbonyl compounds and urea at room temperature.
Conclusion: The zinc chloride in acetic acid found to be an effective greener catalyst system for
Biginelli reaction.
