Background: Mathematical modeling in modified drug release is an important tool that allows
predicting the release rate of drugs in their surrounding environment and elucidates the transport
mechanisms involved in the process.
Objective: The aim of this work was to develop a mathematical model that allows evaluating the release
profile of drugs from polymeric carriers in which the swelling phenomenon is present.
Methods: Swellable matrices based on ionic complexes of alginic acid or carboxymethylcellulose with
ciprofloxacin were prepared and the effect of adding the polymer sodium salt on the swelling process
and the drug release was evaluated. Experimental data from the ciprofloxacin release profiles were
mathematically adjusted, considering the mechanisms involved in each stage of the release process.
Results: A proposed model, named “Dual Release” model, was able to properly fit the experimental
data of matrices presenting the swelling phenomenon, characterized by an inflection point in their release
profile. This entails applying the extended model of Korsmeyer-Peppas to estimate the percentage
of drug released from the first experimental point up to the inflection point and then a model called
Lumped until the final time, allowing to adequately represent the complete range of the drug release
profile. Different parameters of pharmaceutical relevance were calculated using the proposed model to
compare the profiles of the studied matrices.
Conclusion: The “Dual Release” model proposed in this article can be used to predict the behavior of
complex systems in which different mechanisms are involved in the release process.