Infertility in Light of in vitro Fertilization and Intracytoplasmic Sperm Injection: Treatments and Associated Outcomes

Author(s): Nahid Lorzadeh*, Nastran Kazemirad

Journal Name: Current Women`s Health Reviews

Volume 16 , Issue 4 , 2020

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Abstract:

Over the years, the efficacy of assisted reproductive technologies has significantly improved. Infertility-associated problems like tubal obstruction, severe male-factor infertility, severe endometriosis and ovulatory dysfunction have entailed the need for in vitro fertilization (IVF). Intracytoplasmic sperm injection (ICSI) is the insertion of a single and viable spermatozoon into the oocyte, thereby circumventing the penetration of the oocyte membranes and aiding gamete fusion process. The use of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are the most commonly practiced therapeutic measures. However, owing to the report-based outcomes, the success rate is still inconclusive. Besides, there are reports on low pregnancy rates after ICSI, using round spermatids from men, in the absence of elongated spermatids in testes. The use of elongated and round spermatids in ICSI procedures has raised some reasonable doubts regarding the safety of this treatment. In this review, we will give a comprehensive discussion on the role of IVF/ICSI for the treatment of infertility, based on the current researches.

Keywords: Intracytoplasmic sperm injection, in vitro fertilization, assisted reproductive technologies, infertility, spermatids, ovulatory dysfunction.

[1]
Elhussein OG, Ahmed MA, Suliman SO, Yahya LI, Adam I. Epidemiology of infertility and characteristics of infertile couples requesting assisted reproduction in a low-resource setting in Africa, Sudan. Fertil Res Pract 2019; 5: 7.
[http://dx.doi.org/10.1186/s40738-019-0060-1] [PMID: 31360531]
[2]
Practice Committee of American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril 2013; 99(1): 63.
[http://dx.doi.org/10.1016/j.fertnstert.2012.09.023] [PMID: 23095139]
[3]
Beiranvand S, Karimi A, Vahabi S, Amin-Bidokhti A. Comparison of the mean minimum dose of bolus oxytocin for proper uterine contraction during cesarean section. Curr Clin Pharmacol 2019; 14(3): 208-13.
[http://dx.doi.org/10.2174/1574884714666190524100214] [PMID: 31124424]
[4]
Masoumi SZ, Parsa P, Darvish N, Mokhtari S, Yavangi M, Roshanaei G. An epidemiologic survey on the causes of infertility in patients referred to infertility center in Fatemieh Hospital in Hamadan. Iran. J Reprod Med 2015; 13(8): 513-6.
[PMID: 26568755]
[5]
Gleicher N, Kushnir VA, Barad DH. Worldwide decline of IVF birth rates and its probable causes. Hum Reprod Open 2019; 2019(3)hoz017
[http://dx.doi.org/10.1093/hropen/hoz017]
[6]
Tannus S, Son WY, Gilman A, Younes G, Shavit T, Dahan MH. The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age. Hum Reprod 2017; 32(1): 119-24.
[PMID: 27852688]
[7]
Nordhoff V, Fricke RK, Schüring AN, Zitzmann M, Kliesch S. Treatment strategies for severe oligoasthenoteratozoospermia (OAT) (<0.1 million/mL) patients. Andrology 2015; 3(5): 856-63.
[http://dx.doi.org/10.1111/andr.12077] [PMID: 26266459]
[8]
Goswami G, Singh S, Devi MG. Successful fertilization and embryo development after spermatid injection: A hope for nonobstructive azoospermic patients. J Hum Reprod Sci 2015; 8(3): 175-7.
[http://dx.doi.org/10.4103/0974-1208.165147] [PMID: 26538862]
[9]
Hiraoka K, Kitamura S. Clinical efficiency of Piezo-ICSI using micropipettes with a wall thickness of 0.625 μm. J Assist Reprod Genet 2015; 32(12): 1827-33.
[http://dx.doi.org/10.1007/s10815-015-0597-9] [PMID: 26489413]
[10]
Biliangady R, Kinila P, Pandit R, et al. Are we justified doing routine intracytoplasmic sperm injection in nonmale factor infertility? A Retrospective study comparing reproductive outcomes between in vitro fertilization and intracytoplasmic sperm injection in nonmale factor infertility. J Hum Reprod Sci 2019; 12(3): 210-5.
[http://dx.doi.org/10.4103/jhrs.JHRS_8_19] [PMID: 31576078]
[11]
Vloeberghs V, Verheyen G, Tournaye H. Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction? Clinics (São Paulo) 2013; 68(Suppl. 1): 151-6.
[http://dx.doi.org/10.6061/clinics/2013(Sup01)17] [PMID: 23503965]
[12]
Ashrafi M, Jahanian Sadatmahalleh S, Akhoond MR, Ghaffari F, Zolfaghari Z. ICSI outcome in infertile couples with different causes of infertility: a cross-sectional study. Int J Fertil Steril 2013; 7(2): 88-95.
[PMID: 24520469]
[13]
Jain T, Gupta RS. Trends in the use of intracytoplasmic sperm injection in the United States. N Engl J Med 2007; 357(3): 251-7.
[http://dx.doi.org/10.1056/NEJMsa070707] [PMID: 17634460]
[14]
Lorzadeh N, Kazemirad N. Application of stem cells to infertility treatment with emphasis on mesenchymal stem cells and ovarian stem cells. Am J Perinatol 2018; 35(12): 1142-7.
[http://dx.doi.org/10.1055/s-0038-1646948] [PMID: 29715701]
[15]
Lorzadeh N, Kazemirad N. Embryonic stem cells and infertility. Am J Perinatol 2018; 35(10): 925-30.
[http://dx.doi.org/10.1055/s-0038-1632367] [PMID: 29490398]
[16]
De Vos A, Van De Velde H, Joris H, Verheyen G, Devroey P, Van Steirteghem A. Influence of individual sperm morphology on fertilization, embryo morphology, and pregnancy outcome of intracytoplasmic sperm injection. Fertil Steril 2003; 79(1): 42-8.
[http://dx.doi.org/10.1016/S0015-0282(02)04571-5] [PMID: 12524062]
[17]
Lorzadeh N, Samimi SH, Birjandi M. Association of fetal gender with maternal serum β-hCG and testosterone in normotensive and preeclamptic pregnancies. IJOGI 2010; 13(1): 13-9.
[18]
Sousa M, Cremades N, Silva J, et al. Predictive value of testicular histology in secretory azoospermic subgroups and clinical outcome after microinjection of fresh and frozen-thawed sperm and spermatids. Hum Reprod 2002; 17(7): 1800-10.
[http://dx.doi.org/10.1093/humrep/17.7.1800] [PMID: 12093843]
[19]
Tanaka A, Nagayoshi M, Takemoto Y, et al. Fourteen babies born after round spermatid injection into human oocytes. Proc Natl Acad Sci USA 2015; 112(47): 14629-34.
[http://dx.doi.org/10.1073/pnas.1517466112] [PMID: 26575628]
[20]
Sofikitis N, Miyagawa I, Yamamoto Y, Loutradis D, Mantzavinos T, Tarlatzis V. Micro- and macro-consequences of ooplasmic injections of early haploid male gametes. Hum Reprod Update 1998; 4(3): 197-212.
[http://dx.doi.org/10.1093/humupd/4.3.197] [PMID: 9741705]
[21]
Bonduelle M, Wennerholm UB, Loft A, et al. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod 2005; 20(2): 413-9.
[http://dx.doi.org/10.1093/humrep/deh592] [PMID: 15576393]
[22]
Nisker J, Tummon I, Daniel S, Kaplan B, Yuzpe A. Conversion of cycles involving ovarian hyperstimulation with intra-uterine insemination to in-vitro fertilization. Hum Reprod 1994; 9(3): 406-8.
[http://dx.doi.org/10.1093/oxfordjournals.humrep.a138517] [PMID: 8006125]
[23]
Akbariasbagh F, Lorzadeh N, Azmoodeh A, Ghaseminejad A, Mohamadpoor J, Kazemirad S. Association among diameter and volume of follicles, oocyte maturity, and competence in intracytoplasmic sperm injection cycles. Minerva Ginecol 2015; 67(5): 397-403.
[PMID: 26491821]
[24]
Huang JY, Rosenwaks Z. In vitro fertilisation treatment and factors affecting success. Best Pract Res Clin Obstet Gynaecol 2012; 26(6): 777-88.
[http://dx.doi.org/10.1016/j.bpobgyn.2012.08.017] [PMID: 23059403]
[25]
Reindollar RH, Regan MM, Neumann PJ, et al. A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial. Fertil Steril 2010; 94(3): 888-99.
[http://dx.doi.org/10.1016/j.fertnstert.2009.04.022] [PMID: 19531445]
[26]
Schippert C, Garcia-Rocha GJ. Is there still a role for reconstructive microsurgery in tubal infertility? Curr Opin Obstet Gynecol 2011; 23(3): 200-5.
[http://dx.doi.org/10.1097/GCO.0b013e328345522a] [PMID: 21372711]
[27]
Kehinde BA, Abolhassani F, Yazdekhasti H, et al. The effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality in rat ovary. Iran J Basic Med Sci 2016; 19(8): 863-9.
[PMID: 27746868]
[28]
Daitch JA, Bedaiwy MA, Pasqualotto EB, et al. Varicocelectomy improves intrauterine insemination success rates in men with varicocele. J Urol 2001; 165(5): 1510-3.
[http://dx.doi.org/10.1016/S0022-5347(05)66338-0] [PMID: 11342907]
[29]
Cayan S, Erdemir F, Ozbey I, Turek PJ, Kadioğlu A, Tellaloğlu S. Can varicocelectomy significantly change the way couples use assisted reproductive technologies? J Urol 2002; 167(4): 1749-52.
[http://dx.doi.org/10.1016/S0022-5347(05)65192-0] [PMID: 11912402]
[30]
Bhattacharya S, Hamilton MP, Shaaban M, et al. Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial. Lancet 2001; 357(9274): 2075-9.
[http://dx.doi.org/10.1016/S0140-6736(00)05179-5] [PMID: 11445099]
[31]
Ermolovich E, Monahan D, Neri QV, Rosenwaks Z, Palermo G. Premature removal of cumulus cells results in incomplete maturation of cytoplasmic lattices. Hum Reprod 2010; 1: 218.
[32]
Yanagida K, Morozumi K, Katayose H, Hayashi S, Sato A. Successful pregnancy after ICSI with strontium oocyte activation in low rates of fertilization. Reprod Biomed Online 2006; 13(6): 801-6.
[http://dx.doi.org/10.1016/S1472-6483(10)61027-9] [PMID: 17169199]
[33]
Hachem A, Godwin J, Ruas M, et al. PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence. Development 2017; 144(16): 2914-24.
[http://dx.doi.org/10.1242/dev.150227] [PMID: 28694258]
[34]
Yoon SY, Jellerette T, Salicioni AM, et al. Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development. J Clin Invest 2008; 118(11): 3671-81.
[http://dx.doi.org/10.1172/JCI36942] [PMID: 18924610]
[35]
Heindryckx B, Van der Elst J, De Sutter P, Dhont M. Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI. Hum Reprod 2005; 20(8): 2237-41.
[http://dx.doi.org/10.1093/humrep/dei029] [PMID: 15831504]
[36]
Lorzadeh N, Kazemirad S, Lorzadeh M, Najafi S. Comparison of the effect of oral and intravenous fluid therapy on women with oligohydramnios. Res J Obstet Gynecol 2008; 1(1): 25-9.
[http://dx.doi.org/10.3923/rjog.2008.25.29]
[37]
Kashir J, Nomikos M, Lai FA, Swann K. Sperm-induced Ca2+ release during egg activation in mammals. Biochem Biophys Res Commun 2014; 450(3): 1204-11.
[http://dx.doi.org/10.1016/j.bbrc.2014.04.078] [PMID: 24769204]
[38]
Lo Monte G, Murisier F, Piva I, Germond M, Marci R. Focus on intracytoplasmic morphologically selected sperm injection (IMSI): a mini-review. Asian J Androl 2013; 15(5): 608-15.
[http://dx.doi.org/10.1038/aja.2013.54] [PMID: 23832017]
[39]
Sunkara SK, Chinta P, Kamath MS. Perinatal outcomes following assisted reproductive technology. J Hum Reprod Sci 2019; 12(3): 177-81.
[http://dx.doi.org/10.4103/jhrs.JHRS_83_19] [PMID: 31576073]
[40]
Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 2002; 346(10): 725-30.
[http://dx.doi.org/10.1056/NEJMoa010035] [PMID: 11882727]
[41]
Moll AC, Imhof SM, Cruysberg JR, Schouten-van Meeteren AY, Boers M, van Leeuwen FE. Incidence of retinoblastoma in children born after in-vitro fertilisation. Lancet 2003; 361(9354): 309-10.
[http://dx.doi.org/10.1016/S0140-6736(03)12332-X] [PMID: 12559867]
[42]
Gicquel C, Gaston V, Mandelbaum J, Siffroi JP, Flahault A, Le Bouc Y. In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am J Hum Genet 2003; 72(5): 1338-41.
[http://dx.doi.org/10.1086/374824] [PMID: 12772698]
[43]
Belva F, Henriet S, Liebaers I, Van Steirteghem A, Celestin-Westreich S, Bonduelle M. Medical outcome of 8-year-old singleton ICSI children (born≥ 32 weeks’ gestation) and a spontaneously conceived comparison group. Hum Reprod 2006; 22(2): 506-15.
[http://dx.doi.org/10.1093/humrep/del372] [PMID: 16982659]
[44]
Cox GF, Bürger J, Lip V, et al. Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am J Hum Genet 2002; 71(1): 162-4.
[http://dx.doi.org/10.1086/341096] [PMID: 12016591]
[45]
Olivennes F, Mannaerts B, Struijs M, Bonduelle M, Devroey P. Perinatal outcome of pregnancy after GnRH antagonist (ganirelix) treatment during ovarian stimulation for conventional IVF or ICSI: a preliminary report. Hum Reprod 2001; 16(8): 1588-91.
[http://dx.doi.org/10.1093/humrep/16.8.1588] [PMID: 11473947]
[46]
Wilson M, Hartke K, Kiehl M, Rodgers J, Brabec C, Lyles R. Integration of blastocyst transfer for all patients. Fertil Steril 2002; 77(4): 693-6.
[http://dx.doi.org/10.1016/S0015-0282(01)03235-6] [PMID: 11937117]
[47]
Wilson TJ, Lacham-Kaplan O, Gould J, et al. Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating. Mol Reprod Dev 2007; 74(4): 512-9.
[http://dx.doi.org/10.1002/mrd.20644] [PMID: 16998805]
[48]
Rivera-Egea R, Garrido N, Sota N, Meseguer M, Remohí J, Dominguez F. Sperm lipidic profiles differ significantly between ejaculates resulting in pregnancy or not following intracytoplasmic sperm injection. J Assist Reprod Genet 2018; 35(11): 1973-85.
[http://dx.doi.org/10.1007/s10815-018-1284-4] [PMID: 30105539]
[49]
Palermo GD, Neri QV, Schlegel PN, Rosenwaks Z. Intracytoplasmic sperm injection (ICSI) in extreme cases of male infertility. PLoS One 2014; 9(12)e113671
[http://dx.doi.org/10.1371/journal.pone.0113671] [PMID: 25437298]
[50]
Costa-Borges N, Mestres E, Venrell I, Garcia M, Calderón G, Stobrawa S. Intracytoplasmic Sperm Injection (ICSI) in the Mouse with the Eppendorf PiezoXpert®: How to Increase Oocyte Survival Rates After Injection. Application Note No. 395. Available from: https://www.eppendorf.com/product-media/doc/en/327158/Cell-Technology_Application-Note_395_PiezoXpert_TransferMan-4r_VacuTip_Piezo-drill-Tip-Mouse-ICSI-Intracytoplasmic-Sperm-Injection-ICSI-Mouse-Eppendorf-PiezoXpert-How-Increase-Oocyte-Surv.pdf [Accessed on: Mar 15, 2020]


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Article Details

VOLUME: 16
ISSUE: 4
Year: 2020
Published on: 09 September, 2020
Page: [285 - 289]
Pages: 5
DOI: 10.2174/1573404816999200511102307
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