Over the years, the efficacy of assisted reproductive technologies has significantly improved.
Infertility-associated problems like tubal obstruction, severe male-factor infertility, severe
endometriosis and ovulatory dysfunction have entailed the need for in vitro fertilization (IVF). Intracytoplasmic
sperm injection (ICSI) is the insertion of a single and viable spermatozoon into the
oocyte, thereby circumventing the penetration of the oocyte membranes and aiding gamete fusion
process. The use of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are the
most commonly practiced therapeutic measures. However, owing to the report-based outcomes, the
success rate is still inconclusive. Besides, there are reports on low pregnancy rates after ICSI, using
round spermatids from men, in the absence of elongated spermatids in testes. The use of elongated
and round spermatids in ICSI procedures has raised some reasonable doubts regarding the safety of
this treatment. In this review, we will give a comprehensive discussion on the role of IVF/ICSI for
the treatment of infertility, based on the current researches.