Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction

Author(s): Huda Fatima Rajani*, Solmaz Shahidi, Mohammad Mahmoudi Gomari

Journal Name: Current Protein & Peptide Science

Volume 21 , Issue 8 , 2020


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Graphical Abstract:


Abstract:

With an increase in atopic cases and owing to a significant role of mast cells in type I hypersensitivity, a therapeutic need to inhibit degranulation of mast cells has risen. Mast cells are notorious for IgE-mediated allergic response. Advancements have allowed researchers to improve clinical outcomes of already available therapies. Engineered peptides and antibodies can be easily manipulated to attain desired characteristics as per the biological environment. A number of these molecules are designed to target mast cells in order to regulate the release of histamine and other mediators, thereby controlling type I hypersensitivity response. The aim of this review paper is to highlight some of the significant molecules designed for the purpose.

Keywords: Type I hypersensitivity, mast cells, degranulation, peptide engineering, antibody engineering, Fc receptors.

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VOLUME: 21
ISSUE: 8
Year: 2020
Published on: 10 May, 2020
Page: [831 - 841]
Pages: 11
DOI: 10.2174/1389203721666200511094717
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