Acetaminophen Oxidation and Inflammatory Markers – A Review of Hepatic Molecular Mechanisms and Preclinical Studies

Author(s): Silvio Terra Stefanello, Nelson Rodrigues de Carvalho, Simone Beder Reis, Felix Alexandre Antunes Soares, Rômulo Pillon Barcelos*

Journal Name: Current Drug Targets

Volume 21 , Issue 12 , 2020


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Graphical Abstract:


Abstract:

Acetaminophen is a widely used analgesic for pain management, especially useful in chronic diseases, such as rheumatoid arthritis. However, easy access to this medicine has increased the occurrence of episodes of poisoning. Patients often develop severe liver damage, which may quickly lead to death. Consequently, numerous studies have been conducted to identify new biomarkers that allow the prediction of the degree of acetaminophen intoxication and thus intervene in a timely manner to save patients’ lives. This review highlights the main mechanisms of the induction and progression of liver damage arising from acetaminophen poisoning. In addition, we have discussed the possibility of using new clinical biomarkers for detecting acetaminophen poisoning.

Keywords: APAP, biomarkers, intoxication, NAPQI, liver damage, preclinical studies.

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