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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Research Article

The Early Results of Vertebral Pathological Compression Fracture of Extra- nodal Lymphoma with HIV-positive Patients Treated by Percutaneous Kyphoplasty

Author(s): Sheng Sun, Biao Xu, Qiang Zhang*, Chang-song Zhao, Rui Ma, Jie He and Yao Zhang

Volume 18, Issue 4, 2020

Page: [248 - 257] Pages: 10

DOI: 10.2174/1570162X18666200510010207

Price: $65

Abstract

Background: Vertebral pathological compression fracture involving extra-nodal lymphoma impacts negatively on the quality of life of HIV-positive patients. The choice of a safe and effective approach to palliative care in this condition remains a challenge.

Objective: The purpose of this study was to investigate the safety and efficacy of percutaneous kyphoplasty (PKP) in the treatment of vertebral pathological compression fracture of extra-nodal lymphoma in HIV-positive patients.

Methods: A retrospective analysis, from January 2016 to August 2019, was performed on 7 HIVpositive patients, 3 males and 4 females, with extra-nodal lymphoma with a vertebral pathological compression fracture. The patients were treated using percutaneous kyphoplasty in our hospital. Preoperative assessment of the patients was conducted regarding their hematological profile, biochemical indicators, liver and kidney function, blood coagulation function, CD4+T lymphocyte count and viral load. Subsequently, the patients were placed on highly active antiretroviral therapy (HAART) and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP) regimen. Besides, antibiotics, nutritional support and immune-modulating drugs were also administered, rationally. Postoperatively, the height of the anterior edge of the injured vertebrae, Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) values were evaluated. Patients were also monitored for any complications related to the operation.

Results: The average CD4+T cell count for the patients was 164 (range 114 ~247 / ul), while the viral load was 26,269 (range 5,765 ~82,321 copies/ul). All patients received nutritional and immune support and registered significant improvements in the levels of ALB and Hb (P<0.05). In all cases, the operation was uneventful with neither cement leakage nor toxic reactions observed. Similarly, no opportunistic infections, other complications or deaths were reported. The height of the anterior vertebral body and the ODI score of the injured vertebrae were significantly improved immediately after surgery (P<0.05). Compared to the preoperative VAS (7.71±1.11), postoperative values were significantly reduced immediately after surgery (3.85±0.90) and at 2 weeks, 1 month and 6 months post-surgery: 2.71±0.76, 3.29±1.11, and 4.00±0.82, respectively (P<0.01).

Conclusion: Supported with appropriate perioperative treatment measures, PKP is safe and effective in the treatment of pathological vertebral compression fracture due to extra-nodal lymphoma in HIV-positive patients.

Keywords: Percutaneous kyphoplasty, HIV, extra-nodal lymphoma, pathological vertebral compression fractures, perioperative treatment, HAART.

Graphical Abstract
[1]
Qi J, Ding C, Jiang X, Gao Y. Advances in Developing CAR T-Cell Therapy for HIV Cure. Front Immunol 2020; 11: 361.
[http://dx.doi.org/10.3389/fimmu.2020.00361] [PMID: 32210965]
[2]
Bender Ignacio R, Ddungu H, Uldrick TS. Untangling the Effects of Chemotherapy and HIV on CD4 Counts-Implications for Immunotherapy in HIV and Cancer. JAMA Oncol 2019.
[PMID: 31804653]
[3]
Hukuimwe M, Ziruma A, Gidiri MF, Manase M. Large B cell lymphoma presenting as an adnexal mass in an HIV positive patient: a case report. Pan Afr Med J 2019; 33: 290.
[http://dx.doi.org/10.11604/pamj.2019.33.290.19459] [PMID: 31692824]
[4]
Junfeng L, Lina M, Xinyue C. Autologous hematopoietic stem cell transplantation for human immunodeficiency virus associated gastric Burkitt lymphoma: A case report. Medicine (Baltimore) 2019; 98(29) e16222
[http://dx.doi.org/10.1097/MD.0000000000016222] [PMID: 31335672]
[5]
Ramadan KM, Shenkier T, Sehn LH, Gascoyne RD, Connors JM. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann Oncol 2007; 18(1): 129-35.
[http://dx.doi.org/10.1093/annonc/mdl329] [PMID: 17018705]
[6]
Haddad P, Thaell JF, Kiely JM, Harrison EG, Miller RH. Lymphoma of the spinal extradural space. Cancer 1976; 38(4): 1862-6.
[http://dx.doi.org/10.1002/1097-0142(197610)38:4<1862:AID-CNCR2820380467>3.0.CO;2-8] [PMID: 991100]
[7]
Lyons MK, O’Neill BP, Marsh WR, Kurtin PJ. Primary spinal epidural non-Hodgkin’s lymphoma: report of eight patients and review of the literature. Neurosurgery 1992; 30(5): 675-80.
[PMID: 1584377]
[8]
Jacobs WB, Perrin RG. Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus 2001; 11(6) e10
[http://dx.doi.org/10.3171/foc.2001.11.6.11] [PMID: 16463993]
[9]
De Marinis F, Eberhardt W, Harper PG, et al. Bisphosphonate use in patients with lung cancer and bone metastases: recommendations of a European expert panel. J Thorac Oncol 2009; 4(10): 1280-8.
[http://dx.doi.org/10.1097/JTO.0b013e3181b68e5a] [PMID: 19701109]
[10]
Maranzano E, Trippa F, Casale M, et al. 8Gy single-dose radiotherapy is effective in metastatic spinal cord compression: results of a phase III randomized multicentre Italian trial. Radiother Oncol 2009; 93(2): 174-9.
[http://dx.doi.org/10.1016/j.radonc.2009.05.012] [PMID: 19520448]
[11]
Akbar M, Ayache A, Eichler M, Klotz M, Wiedenhöfer B, Lehner B. Management of spinal metastases, strategies and surgical indications Orthopade 2012; 41(8): 632-9.
[http://dx.doi.org/10.1007/s00132-012-1910-2] [PMID: 22850832]
[12]
Mac Manus MP, Hicks RJ, Matthews JP, Wirth A, Rischin D, Ball DL. Metabolic (FDG-PET) response after radical radiotherapy/chemoradiotherapy for non-small cell lung cancer correlates with patterns of failure. Lung Cancer 2005; 49(1): 95-108.
[http://dx.doi.org/10.1016/j.lungcan.2004.11.024] [PMID: 15949595]
[13]
Yao A, Sarkiss CA, Ladner TR, Jenkins AL III. Contemporary spinal oncology treatment paradigms and outcomes for metastatic tumors to the spine: A systematic review of breast, prostate, renal, and lung metastases. J Clin Neurosci 2017; 41: 11-23.
[http://dx.doi.org/10.1016/j.jocn.2017.04.004] [PMID: 28462790]
[14]
Kaloostian PE, Yurter A, Etame AB, Vrionis FD, Sciubba DM, Gokaslan ZL. Palliative strategies for the management of primary and metastatic spinal tumors. Cancer Contr 2014; 21(2): 140-3.
[http://dx.doi.org/10.1177/107327481402100206] [PMID: 24667400]
[15]
Lee BH, Kim TH, Chong HS, et al. Prognostic factor analysis in patients with metastatic spine disease depending on surgery and conservative treatment: review of 577 cases. Ann Surg Oncol 2013; 20(1): 40-6.
[http://dx.doi.org/10.1245/s10434-012-2644-4] [PMID: 22956070]
[16]
Xing D, Ma JX, Ma XL, et al. A meta-analysis of balloon kyphoplasty compared to percutaneous vertebroplasty for treating osteoporotic vertebral compression fractures. J Clin Neurosci 2013; 20(6): 795-803.
[http://dx.doi.org/10.1016/j.jocn.2012.05.038] [PMID: 23428914]
[17]
Brodano GB, Amendola L, Martikos K, et al. Vertebroplasty: benefits are more than risks in selected and evidence-based informed patients. A retrospective study of 59 cases. Eur Spine J 2011; 20(8): 1265-71.
[http://dx.doi.org/10.1007/s00586-011-1705-x] [PMID: 21318281]
[18]
Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy. Geneva: World Health Organization 2017.
[19]
European AIDS Clinical Society. EACS Guidelines(Version9.0). 2017[S/OL][2018-10-02] 2017.http://www.eacsociety.org/files/guidelines_9.0-English. pdf
[20]
Bahebeck J, Eone DH, Nonga BN, Kingue TN, Sosso M. Implant orthopaedic surgery in HIV asymptomatic carriers: management and early outcome. Injury 2009; 40(11): 1147-50.
[http://dx.doi.org/10.1016/j.injury.2008.12.012] [PMID: 19467653]
[21]
Lim RMH, Chan NPX, Khoo LP, et al. A Clinico-Genotypic Prognostic Index for De Novo Composite Diffuse Large B-Cell Lymphoma Arising from Follicular Lymphoma in Asian patients treated in the Rituximab Era. Sci Rep 2020; 10(1): 4373.
[http://dx.doi.org/10.1038/s41598-020-61378-4] [PMID: 32152442]
[22]
Wang H, Zhang Z, Liu Y, Jiang W. Percutaneous kyphoplasty for the treatment of very severe osteoporotic vertebral compression fractures with spinal canal compromise. J Orthop Surg Res 2018; 13(1): 13.
[http://dx.doi.org/10.1186/s13018-018-0719-z] [PMID: 29343287]
[23]
Gopal S, Patel MR, Yanik EL, et al. Temporal trends in presentation and survival for HIV-associated lymphoma in the antiretroviral therapy era. J Natl Cancer Inst 2013; 105(16): 1221-9.
[http://dx.doi.org/10.1093/jnci/djt158] [PMID: 23892362]
[24]
Raúl U, Meredith S, Robert D, et al. Spectrum of cancer risk among HIV-infected people in the United States during the modern antiretroviral therapy era: a population-based registry linkage study. Lancet HIV 2017; 4(11): e495-504.
[PMID: 28803888]
[25]
Shiels MS, Engels EA. Evolving epidemiology of HIV-associated malignancies. Curr Opin HIV AIDS 2017; 12(1): 6-11.
[http://dx.doi.org/10.1097/COH.0000000000000327] [PMID: 27749369]
[26]
Xiao J, Gao G, Li Y, et al. Spectrums of infectious complications and malignancies in HIV-infected patients in tertiary care hospital, China PLoS One 2013. 8e75915
[http://dx.doi.org/10.1371/journal.pone.0075915] [PMID: 24204583]
[27]
Franceschi S, Lise M, Clifford GM, et al. Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study. Br J Cancer 2010; 103(3): 416-22.
[http://dx.doi.org/10.1038/sj.bjc.6605756] [PMID: 20588274]
[28]
Hleyhel M, Belot A, Bouvier AM, et al. Risk of AIDS-defining cancers among HIV-1-infected patients in France between 1992 and 2009: results from the FHDH-ANRS CO4 cohort. Clin Infect Dis 2013; 57(11): 1638-47.
[http://dx.doi.org/10.1093/cid/cit497] [PMID: 23899679]
[29]
Robbins HA, Shiels MS, Pfeiffer RM, Engels EA. Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States. AIDS 2014; 28(6): 881-90.
[http://dx.doi.org/10.1097/QAD.0000000000000163] [PMID: 24300545]
[30]
Gibson TM, Morton LM, Shiels MS, Clarke CA, Engels EA. Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study. AIDS 2014; 28(15): 2313-8.
[http://dx.doi.org/10.1097/QAD.0000000000000428] [PMID: 25111081]
[31]
Naresh KN, Srinivas V, Soman CS. Distribution of various subtypes of non-Hodgkin’s lymphoma in India: a study of 2773 lymphomas using R.E.A.L. and WHO Classifications. Ann Oncol 2000; 11(Suppl. 1): 63-7.
[http://dx.doi.org/10.1093/annonc/11.suppl_1.S63] [PMID: 10707782]
[32]
Pasqualucci L, Dalla-Favera R. SnapShot: diffuse large B cell lymphoma. Cancer Cell 2014; 25(1): 132-132.e1.
[http://dx.doi.org/10.1016/j.ccr.2013.12.012] [PMID: 24434215]
[33]
Ollila TA, Olszewski AJ. Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence. Curr Treat Options Oncol 2018; 19(8): 38.
[http://dx.doi.org/10.1007/s11864-018-0555-8] [PMID: 29931605]
[34]
Wang L, Ouayang T, Zhang N, et al. Primary Diffuse Large B-Cell Dural Lymphoma With Bone and Subcutaneous Tissue Involvement Mimicking Meningioma. J Craniofac Surg 2015; 26(6): e492-4.
[http://dx.doi.org/10.1097/SCS.0000000000002007] [PMID: 26221858]
[35]
Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007; 114(2): 97-109.
[http://dx.doi.org/10.1007/s00401-007-0243-4] [PMID: 17618441]
[36]
List AF. Metastatic giant-cell bone tumor in a man positive for HIV. N Engl J Med 1988; 318(8): 517.
[http://dx.doi.org/10.1056/NEJM198802253180813] [PMID: 3340133]
[37]
Johnson RW, Suva LJ. Hallmarks of Bone Metastasis. Calcif Tissue Int 2018; 102(2): 141-51.
[http://dx.doi.org/10.1007/s00223-017-0362-4] [PMID: 29138883]
[38]
Jeong HM, Cho SW, Park SI. Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment. Endocrinol Metab (Seoul) 2016; 31(4): 485-92.
[http://dx.doi.org/10.3803/EnM.2016.31.4.485] [PMID: 28029019]
[39]
Bostel T, Förster R, Schlampp I, et al. Stability and survival analysis of elderly patients with osteolytic spinal bone metastases after palliative radiotherapy: Results from a large multicenter cohort. Strahlenther Onkol 2019; 195(12): 1074-85.
[http://dx.doi.org/10.1007/s00066-019-01482-1] [PMID: 31240346]
[40]
Barzilai O, Boriani S, Fisher CG, et al. Essential Concepts for the Management of Metastatic Spine Disease: What the Surgeon Should Know and Practice. Global Spine J 2019; 9(1)(Suppl.): 98S-107S.
[http://dx.doi.org/10.1177/2192568219830323] [PMID: 31157152]
[41]
Barzilai O, Laufer I, Yamada Y, et al. Integrating evidence-based medicine for treatment of spinal metastases into a decision framework: neurologic, oncologic, mechanicals stability, and systemic disease. J Clin Oncol 2017; 35(21): 2419-27.
[http://dx.doi.org/10.1200/JCO.2017.72.7362] [PMID: 28640703]
[42]
Hussain I, Barzilai O, Reiner AS, et al. Patient-reported outcomes after surgical stabilization of spinal tumors: symptom-based validation of the Spinal Instability Neoplastic Score (SINS) and surgery. Spine J 2018; 18(2): 261-7.
[http://dx.doi.org/10.1016/j.spinee.2017.07.008] [PMID: 28713049]
[43]
Sun S, Zhang Y-S, Zhang Q, et al. Ultrasonic scalpel treatment for HIV positive patients with giant cell tumor of long bone. Int J Clin Exp Med 2017; 10(4): 6853-60.
[44]
Mylvaganam G, Yanez AG, Maus M, Walker BD, Toward T. Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology. Front Immunol 2019; 10: 2109.
[http://dx.doi.org/10.3389/fimmu.2019.02109] [PMID: 31552045]
[45]
Titanji K, Vunnava A, Foster A, et al. T-cell receptor activator of nuclear factor-κB ligand/osteoprotegerin imbalance is associated with HIV-induced bone loss in patients with higher CD4+ T-cell counts. AIDS 2018; 32(7): 885-94.
[http://dx.doi.org/10.1097/QAD.0000000000001764] [PMID: 29424771]
[46]
Neale Weitzmann Bone M. Immune System. Toxicol Pathol 2017; 45(7): 911-24.
[47]
Bedi B, Li JY, Grassi F, Tawfeek H, Weitzmann MN, Pacifici R. Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss. Ann N Y Acad Sci 2010; 1192: 215-21.
[http://dx.doi.org/10.1111/j.1749-6632.2009.05216.x] [PMID: 20392239]
[48]
Cenci S, Weitzmann MN, Roggia C, et al. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest 2000; 106(10): 1229-37.
[http://dx.doi.org/10.1172/JCI11066] [PMID: 11086024]
[49]
Ono T, Hayashi M, Sasaki F, Nakashima T. RANKL biology: bone metabolism, the immune system, and beyond. Inflamm Regen 2020; 40: 2.
[http://dx.doi.org/10.1186/s41232-019-0111-3] [PMID: 32047573]
[50]
McGinty T, Mirmonsef P, Mallon PW, Landay AL. Does systemic inflammation and immune activation contribute to fracture risk in HIV? Curr Opin HIV AIDS 2016; 11(3): 253-60.
[http://dx.doi.org/10.1097/COH.0000000000000275] [PMID: 27008474]
[51]
Maccauro G, Spinelli MS, Mauro S, Perisano C, Graci C, Rosa MA. Physiopathology of spine metastasis. Int J Surg Oncol 2011; 2011 107969
[http://dx.doi.org/10.1155/2011/107969] [PMID: 22312491]
[52]
Sharma A, Shi Q, Hoover DR, et al. Increased fracture incidence in middle-aged HIV-infected and HIV-uninfected women: updated results from the women’s interagency HIV study. J Acquir Immune Defic Syndr 2015; 70(1): 54-61.
[http://dx.doi.org/10.1097/QAI.0000000000000674] [PMID: 26322667]
[53]
Chokotho L, Harrison WJ, Lubega N, Mkandawire NC. Avascular necrosis of the femoral head in HIV positive patients-an assessment of risk factors and early response to surgical treatment. Malawi Med J 2013; 25(2): 28-32.
[PMID: 24098826]
[54]
Hao J, Herbert B, Quispe JC, et al. An observational case series of HIV-positive patients treated with open reduction internal fixation for a closed lower extremity fracture. Eur J Orthop Surg Traumatol 2015; 25(5): 815-9.
[http://dx.doi.org/10.1007/s00590-015-1595-4] [PMID: 25649316]
[55]
Abalo A, Patassi A, James YE, Walla A, Sangare A, Dossim A. Risk factors for surgical wound infection in HIV-positive patients undergoing surgery for orthopaedic trauma. J Orthop Surg (Hong Kong) 2010; 18(2): 224-7.
[http://dx.doi.org/10.1177/230949901001800218] [PMID: 20808017]
[56]
Richardson J, Hill AM, Johnston CJ. J Bone Jt Surg Br 2008; 90(8): 988-94.
[http://dx.doi.org/10.1302/0301-620X.90B8.20861]
[57]
Aird J, Noor S, Lavy C, Rollinson P. The effect of HIV on early wound healing in open fractures treated with internal and external fixation. J Bone Joint Surg Br 2011; 93(5): 678-83.
[http://dx.doi.org/10.1302/0301-620X.93B5.26081] [PMID: 21511935]
[58]
Zhao CS, Li X, Zhang Q, Sun S, Zhao RG, Cai J. Early Outcomes of Primary Total Hip Arthroplasty for Osteonecrosis of the Femoral Head in Patients with Human Immunodeficiency Virus in China. Chin Med J (Engl) 2015; 128(15): 2059-64.
[http://dx.doi.org/10.4103/0366-6999.161364] [PMID: 26228219]
[59]
Howard NE, Phaff M, Aird J, Wicks L, Rollinson P. Does human immunodeficiency virus status affect early wound healing in open surgically stabilised tibial fractures?: A prospective study. Bone Joint J 2013; 95-B(12): 1703-7.
[http://dx.doi.org/10.1302/0301-620X.95B12.32083] [PMID: 24293603]
[60]
Gardner RO, Bates JH, Ng’oma E, Harrison WJ. Fracture union following internal fixation in the HIV population. Injury 2013; 44(6): 830-3.
[http://dx.doi.org/10.1016/j.injury.2012.11.024] [PMID: 23267724]
[61]
Wijesekera MP, Graham SM, Lalloo DG, Simpson H, Harrison WJ. Fracture management in HIV positive individuals: a systematic review. Int Orthop 2016; 40(12): 2429-45.
[http://dx.doi.org/10.1007/s00264-016-3285-1] [PMID: 27655034]
[62]
Fujita Y, Otsuki H, Watanabe Y, et al. Generation of a replication-competent chimeric simian-human immunodeficiency virus carrying env from subtype C clinical isolate through intracellular homologous recombination. Virology 2013; 436(1): 100-11.
[http://dx.doi.org/10.1016/j.virol.2012.10.036] [PMID: 23219366]
[63]
Ruiz A, Schmitt K, Culley N, Stephens EB. Simian-Human immunodeficiency viruses expressing chimeric subtype B/C Vpu proteins demonstrate the importance of the amino terminal and transmembrane domains in the rate of CD4(+) T cell loss in macaques. Virology 2013; 435(2): 395-405.
[http://dx.doi.org/10.1016/j.virol.2012.10.030] [PMID: 23218949]
[64]
Rahmati H, Sharif F, Davarpanah MA. Surgeon’s satisfaction on the use of invented needle magnet in reducing the risk of sharp injuries in the operating room. Niger Med J 2014; 55(3): 220-3.
[http://dx.doi.org/10.4103/0300-1652.132044] [PMID: 25013253]
[65]
Guild GN, Moore TJ, Barnes W, Hermann C. CD4 count is associated with postoperative infection in patients with orthopaedic trauma who are HIV positive. Clin Orthop Relat Res 2012; 470(5): 1507-12.
[http://dx.doi.org/10.1007/s11999-011-2223-1] [PMID: 22207561]
[66]
Rasulova N, Lyubshin V, Djalalov F, et al. Strategy for bone metastases treatment in patients with impending cord compression or vertebral fractures: a pilot study. World J Nucl Med 2011; 10(1): 14-9.
[http://dx.doi.org/10.4103/1450-1147.82114] [PMID: 22034578]
[67]
Pan H, Simpson DR, Mell LK, Mundt AJ, Lawson JD. A survey of stereotactic body radiotherapy use in the United States. Cancer 2011; 117(19): 4566-72.
[http://dx.doi.org/10.1002/cncr.26067] [PMID: 21412761]
[68]
Smith MR, Coleman RE, Klotz L, et al. Denosumab for the prevention of skeletal complications in metastatic castration-resistant prostate cancer: comparison of skeletal-related events and symptomatic skeletal events. Ann Oncol 2015; 26(2): 368-74.
[http://dx.doi.org/10.1093/annonc/mdu519] [PMID: 25425475]
[69]
Wang X, Yang KH, Wanyan P, Tian JH. Comparison of the efficacy and safety of denosumab versus bisphosphonates in breast cancer and bone metastases treatment: A meta-analysis of randomized controlled trials. Oncol Lett 2014; 7(6): 1997-2002.
[http://dx.doi.org/10.3892/ol.2014.1982] [PMID: 24932278]
[70]
MacManus MR, Hicks R, Fisher R, et al. FDG-PET-detected extracranial metastasis in patients with non-small cell lung cancer undergoing staging for surgery or radical radiotherapy--survival correlates with metastatic disease burden. Acta Oncol 2003; 42(1): 48-54.
[http://dx.doi.org/10.1080/0891060310002230] [PMID: 12665331]
[71]
Mossa-Basha M, Gerszten PC, Myrehaug S, et al. Spinal metastasis: diagnosis, management and follow-up. Br J Radiol 2019; 92(1103) 20190211
[http://dx.doi.org/10.1259/bjr.20190211] [PMID: 31322920]
[72]
Klimo P Jr, Thompson CJ, Kestle JR, Schmidt MH. A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro-oncol 2005; 7(1): 64-76.
[http://dx.doi.org/10.1215/S1152851704000262] [PMID: 15701283]
[73]
Kim JM, Losina E, Bono CM, et al. Clinical outcome of metastatic spinal cord compression treated with surgical excision ± radiation versus radiation therapy alone: a systematic review of literature. Spine 2012; 37(1): 78-84.
[http://dx.doi.org/10.1097/BRS.0b013e318223b9b6] [PMID: 21629164]
[74]
Fomin DK, Smirnov IuN, Tararukhina OB, Nazarov AA. Strontium chloride (89Sr-chloride) fractional injection method for bone metastases treatment Vopr Onkol 2012; 58(1): 116-8.
[PMID: 22629840]
[75]
Baczyk M, Czepczyński R, Milecki P, Pisarek M, Oleksa R, Sowiński J. 89Sr versus 153Sm-EDTMP: comparison of treatment efficacy of painful bone metastases in prostate and breast carcinoma. Nucl Med Commun 2007; 28(4): 245-50.
[http://dx.doi.org/10.1097/MNM.0b013e32805b72a0] [PMID: 17325585]
[76]
Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine 2001; 26(3): 298-306.
[http://dx.doi.org/10.1097/00007632-200102010-00016] [PMID: 11224867]
[77]
Dobran M, Iacoangeli M, Brunozzi D, et al. Surgical treatments of spinal metastases: analysis of prognostic factors during a seven-year experience. J Neurosurg Sci 2018; 62(1): 94-7.
[PMID: 27845506]
[78]
Spratt DE, Beeler WH, de Moraes FY, et al. An integrated multidisciplinary algorithm for the management of spinal metastases: an International Spine Oncology Consortium report. Lancet Oncol 2017; 18(12): e720-30.
[http://dx.doi.org/10.1016/S1470-2045(17)30612-5] [PMID: 29208438]
[79]
Bartels RHMA, van der Linden YM, van der Graaf WT. Spinal extradural metastasis: review of current treatment options. CA Cancer J Clin 2008; 58(4): 245-59.
[http://dx.doi.org/10.3322/CA.2007.0016] [PMID: 18354080]
[80]
Parthiban JK, Rudrappa S, Prahlad ST, Govindasamy R. Evolution of surgical techniques in the management of vertebral body tumours and the current status. Neurol India 2018; 66(5): 1254-69.
[http://dx.doi.org/10.4103/0028-3886.241398] [PMID: 30232982]
[81]
Boriani S, Gasbarrini A, Bandiera S, Ghermandi R, Lador R. En Bloc Resections in the Spine: The Experience of 220 Patients During 25 Years. World Neurosurg 2017; 98: 217-29.
[http://dx.doi.org/10.1016/j.wneu.2016.10.086] [PMID: 27794510]
[82]
Patchell RA, Tibbs PA, Regine WF, et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 2005; 366(9486): 643-8.
[http://dx.doi.org/10.1016/S0140-6736(05)66954-1] [PMID: 16112300]
[83]
Papanastassiou ID, Filis AK, Gerochristou MA, Vrionis FD. Controversial issues in kyphoplasty and vertebroplasty in malignant vertebral fractures. Cancer Contr 2014; 21(2): 151-7.
[http://dx.doi.org/10.1177/107327481402100208] [PMID: 24667402]
[84]
Xiao H, Yang J, Feng X, et al. Comparing complications of vertebroplasty and kyphoplasty for treating osteoporotic vertebral compression fractures: a meta-analysis of the randomized and non-randomized controlled studies. Eur J Orthop Surg Traumatol 2015; 25(Suppl. 1): S77-85.
[http://dx.doi.org/10.1007/s00590-014-1502-4] [PMID: 24989933]
[85]
Yaltirik K, Ashour AM, Reis CR, Özdoğan S, Atalay B. Vertebral augmentation by kyphoplasty and vertebroplasty: 8 years experience outcomes and complications. J Craniovertebr Junction Spine 2016; 7(3): 153-60.
[http://dx.doi.org/10.4103/0974-8237.188413] [PMID: 27630477]
[86]
Wang Y, Liu H, Pi B, Yang H, Qian Z, Zhu X. Clinical evaluation of percutaneous kyphoplasty in the treatment of osteolytic and osteoblastic metastatic vertebral lesions. Int J Surg 2016; 30: 161-5.
[http://dx.doi.org/10.1016/j.ijsu.2016.02.031] [PMID: 26873520]

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