Etoricoxib and Herbal Adjuvant Containing Nanoparticles Incorporated Gel and Ointment Formulations for the Treatment of Human Skin Melanoma (SK-MEL-2)

(E-pub Ahead of Print)

Author(s): Rashmi Sharma, Rishabha Malviya*.

Journal Name: Nanoscience & Nanotechnology-Asia

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Aim: The aim of study was to develop nanoparticles consisting etoricoxib with ethanolic extract of ginger rhizome (GE) and basil leaves (BE) and evaluated against human skin cancer cells (melanoma, SK-MEL-2). Nanoparticles were further incorporated into gel and ointment and characterized.

Material: Concentration of extract was varied while etoricoxib remains constant in nanoparticles. Nanoparticles were incorporated into gel and ointment, prepared by using tamarind seed polysaccharide and aloe vera gel, respectively.

Result: All the batches of nanoparticles were evaluated for particle size and were found from 924 nm (N1) to 1084 nm (N9). The loading efficiency of etoricoxib varied form 66.8±0.05 % (N4) to 85.1±0.04 % (N9), for GE 60.3±0.04 % (N4) to 72.1±0.05 % (N9), for BE 59.5±0.04 % (N8) to 80.5±0.03 % (N9). The consistency of ointment and gel was found smooth and no greediness observed. The pH of the nanoparticles incorporated ointment was observed 6.2±0.023 (O6) to 6.2±0.089 (O4), viscosity was found from 0.70±0.098 (O3) to 1.130±0.092 (O1) gm/cm3 , spreadability in the range of 58.3±0.062 (O2) to 66.2±0.098 (O5) %. The pH of nanoparticles incorporated gel was observed 6.2±0.019 (G2) to 6.2±0.098 (G7), viscosity was found from 0.847±0.030 (G7) to 1.130±0.065 gm/cm3 (G9), spreadability in the range of 62.5±0.045 % (G5) to 70.51±0.056 % (G4). In vitro cytotoxic studies showed that nanoparticles incorporated gel formulation (G1) was able to control cell grown (SK-MEL-2).

Conclusion: It can be concluded that etoricoxib and herbal components consisting formulations were able to control human skin cancer cells.

Keywords: Nanoparticles, gel formulation, herbal adjuvant, skin cancer, etoricoxib

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(E-pub Ahead of Print)
DOI: 10.2174/2210681210999200509233724
Price: $95