Aim: The aim of study was to develop nanoparticles consisting etoricoxib with ethanolic extract of ginger rhizome (GE) and basil leaves
(BE) and evaluated against human skin cancer cells (melanoma, SK-MEL-2). Nanoparticles were further incorporated into gel and ointment and
Material: Concentration of extract was varied while etoricoxib remains constant in nanoparticles. Nanoparticles were incorporated into gel and
ointment, prepared by using tamarind seed polysaccharide and aloe vera gel, respectively.
Result: All the batches of nanoparticles were evaluated for particle size and were found from 924 nm (N1) to 1084 nm (N9). The loading efficiency
of etoricoxib varied form 66.8±0.05 % (N4) to 85.1±0.04 % (N9), for GE 60.3±0.04 % (N4) to 72.1±0.05 % (N9), for BE 59.5±0.04 % (N8) to
80.5±0.03 % (N9). The consistency of ointment and gel was found smooth and no greediness observed. The pH of the nanoparticles incorporated
ointment was observed 6.2±0.023 (O6) to 6.2±0.089 (O4), viscosity was found from 0.70±0.098 (O3) to 1.130±0.092 (O1) gm/cm3
, spreadability in
the range of 58.3±0.062 (O2) to 66.2±0.098 (O5) %. The pH of nanoparticles incorporated gel was observed 6.2±0.019 (G2) to 6.2±0.098 (G7),
viscosity was found from 0.847±0.030 (G7) to 1.130±0.065 gm/cm3
(G9), spreadability in the range of 62.5±0.045 % (G5) to 70.51±0.056 % (G4). In
vitro cytotoxic studies showed that nanoparticles incorporated gel formulation (G1) was able to control cell grown (SK-MEL-2).
Conclusion: It can be concluded that etoricoxib and herbal components consisting formulations were able to control human skin cancer cells.