Title:Current Status of Drug Delivery Approaches and Assay of Anti-Migraine Drugs
VOLUME: 18 ISSUE: 2
Author(s):Ozgur Esim, Ayhan Savaser, Leyla Karadurmus, Nurgul K. Bakirhan, Sibel A. Ozkan and Yalcin Ozkan*
Affiliation:Department of Pharmaceutical Technology, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara, Department of Pharmaceutical Technology, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Adıyaman University, Adıyaman, Department of Analytical Chemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, University of Ankara, Ankara 06100, Department of Pharmaceutical Technology, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara
Keywords:Antimigraine drugs, drug delivery system, HPLC, UV spectrophotometry, electrochemical analysis, CNS drug
delivery.
Abstract:Migraine is a chronic, painful, neurological disorder that affects approximately 15% of the
population worldwide. It is a form of neurovascular headache: a disorder in which neural events result
in the dilation of blood vessels that, in turn, results in pain and further nerve activation. The pathogenesis
of migraine is not completely understood, but it is thought that both central and peripheral
stimulations can play a role in migraine. Experimental pharmacological evidence suggests that some
drugs can have actions in migraine treatment and oral drug delivery is the first choice for these drugs.
However, the oral absorption of many drugs is delayed during migraine attacks. Therefore, there may
be an advantage to other drug delivery routes, such as parenteral and intranasal. Moreover, nanoparticles
can be used for improved drug delivery of anti-migraine agents as they can protect the encapsulated
drug from biological and/or chemical degradation, and extracellular transport by P-gp efflux
proteins. Various analytical studies have been performed to sensitive and selective assays of antimigraine
drugs from commercial and real samples. Anti-migraines, either single or combined with
other drugs, can be easily detected by several analytical methods, such as ultraviolet spectrometry,
visible spectrometry, high-performance liquid chromatography, liquid chromatography-mass spectrometry,
and high-performance thin layer chromatography. This review focuses on the status of antimigraine
drug delivery technologies and possible routes for drug delivery. Moreover, it will present
their analytical assays with different methods.
