Background: The existing methods of analyte detection by various biochemical processes
have certain drawbacks including nonlinearity and detection limits. The nanotechnology has paved a
way for the development of new devices i.e., nano-biosensors, by amalgamation of nanoparticles
with recognition elements. These nano-biosensors have the capabilities to overcome the drawbacks
of conventional methods.
Objectives: Present study was planned to analyze the biosensing potential of indium tin oxide (ITO)
electrode modified with gold nanoparticles synthesized using aqueous extract of S. podophyllum.
Methods: In present study, first time rapid green synthesis of gold nanoparticles from leaf extract of
Syngonium podophyllum is reported. The synthesized nanoparticles were then characterized physically
by UV-Visible spectroscopy, particle size analysis, fluorescent spectroscopy, Fourier transform
infrared spectroscopy and transmission electron microscopy (TEM), and HR (High resolution)-TEM.
Results: The particles were observed to be in average size range of 30-70 nm. Furthermore, the ITO
electrode was modified with the prepared nanoparticles and analyzed by ellipsometry. The electrochemical
characteristics of the modified electrodes were analyzed by cyclic voltammetry.
Conclusion: The results exhibited a higher current gain, thus signifying a higher signal amplification
at the electrodes and paves the way for their use in electrochemical nanobiosensors.