Pyrimidine heterocycles are proven to be biologically active heterocycles,
found in many biological systems, displaying a broad spectrum of biological activities including
anticancer, anxiolytic, antioxidant, antiviral, antifungal, anticonvulsant, antidepressant
and antibacterial activities. Recently, various synthetic approaches, synthetic
strategy, the variation of substrates and study devoted towards the evaluation of biological
activities for the pyrimidine heterocycles have been reported in the literature. This review
article describes the synthesis of various biologically interesting pyrimidine heterocyclic
ring systems using various nitrogen building blocks.
Keywords: Pyrimidine, ammonium acetate, nitrile, amidine, guanidine, Biginelli reaction, dihydropyrimidones, cycloaddition reaction.
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