Anticoagulant Activity of Sulfated Polysaccharides and Polyphenols Extracted from Marine Algae

(E-pub Ahead of Print)

Author(s): Karima Saidani*, Nadia Ziani, Naima Touati, Hafida Merzouk, Fatiha Bedjou

Journal Name: Current Bioactive Compounds

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The aim of this study was to evaluate the anticoagulant activity of five marine algae from Bejaia’s coast (Algeria). Higher contents of phenolic compounds were obtained with ethanol for Cystoseira humilis, Halopteris scoparia, Padina pavonica and Rhodomela confervoides (8.55±0.29, 7.84±0.47, 6.41±0.14 and 4.16±0.04 mg CE/g of dw, respectively). Whereas, for Sargassum vulgare, the extraction with acetone showed higher content (3.04±0.071 mg CE/g of dw).The determination of sugar content showed that acetone extract of the five seaweeds was the richest in sugar, this rate increasingly dropped in ethanol extract and the fractions A and B. The red algae Rhodomela confervoides showed a significant anticoagulant activity in ethanol extract and the fractions A, B and C, with an elongation up to 407.97±58.12 s in the fraction C, at a concentration of 10 mg/mL. An anticoagulant activity was observed in the fractions A, B and C of all the brown seaweeds. A procoagulant activity was observed in the fractions A, B of Cystoseira humilis and Sargassum vulgare as well as the fraction B of Padina pavonica with an indeterminate period, at 10 mg/mL.

Keywords: anticoagulant activity, marine algae, phenolic compounds, sufated polysaccharides.

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(E-pub Ahead of Print)
DOI: 10.2174/1573407216999200507123017
Price: $95

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