The pandemic novel coronavirus disease (COVID-19) has become a global concern in
which the respiratory system is not the only one involved. Previous researches have presented the
common clinical manifestations including respiratory symptoms (i.e., fever and cough), fatigue and
myalgia. However, there is limited evidence for neurological and psychological influences of
SARS-CoV-2. In this review, we discuss the common neurological manifestations of COVID-19
including acute cerebrovascular disease (i.e., cerebral hemorrhage) and muscle ache. Possible viral
transmission to the nervous system may occur via circulation, an upper nasal transcribrial route
and/or conjunctival route. Moreover, we cannot ignore the psychological influence on the public,
medical staff and confirmed patients. Dealing with public psychological barriers and performing
psychological crisis intervention are an important part of public health interventions.
Keywords: Brain, indirect influence, neurological, SARS-COV-2, psychological, mental health, COVID-19, transmission.
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