The use of neuroprotective agents for stroke is pathogenetically justified, but the translation
of the results of preclinical studies of neuroprotectors into clinical practice has been a noticeable
failure. One of the leading reasons for these failures is the one-target mechanism of their activity.
p-Tyrosol (Tyr), a biophenol, is present in a variety of natural sources, mainly in foods, such as
olive oil and wine. Tyr has a wide spectrum of biological activity: antioxidant, stress-protective,
anti-inflammatory, anticancer, cardioprotective, neuroprotective and many others. This review analyzes
data on the neuroprotective, antioxidant, anti-inflammatory, anti-apoptotic and other kinds of
Tyr activity as well as data on the pharmacokinetics of the substance. The data presented in the
review substantiate the acceptability of tyr as the basis for the development of a new neuroprotective
drug with multitarget activity for the treatment of ischemic stroke. Tyr is a promising molecule
for the development of an effective neuroprotective agent for use in ischemic stroke.