Background: Mulberry, including several species belonging to genus Morus, has been
widely used as a traditional medicine for a long time. Extracts and active components of mulberry
have many positive neurological and biological effects and can become potential candidates in the
search for new drugs for neurological disorders.
Objectives: We aimed to systematically review the medical literature for evidence of mulberry effects
on the central nervous system.
Methods: We conducted a systematic search in nine databases. We included all in vivo studies investigating
the effect of mulberry on the central nervous system with no restrictions.
Results: We finally included 47 articles for quality synthesis. Our findings showed that mulberry
and its components possessed an antioxidant effect, showed a reduction in the cerebral infarct volume
after stroke. They also improved the cognitive function, learning process, and reduced memory
impairment in many animal models. M. alba and its extracts ameliorated Parkinson's disease-like
behaviors, limited the complications of diabetes mellitus on the central nervous system, possessed
anti-convulsant, anti-depressive, and anxiolytic effects.
Conclusion: Mulberry species proved beneficial to many neurological functions in animal models.
The active ingredients of each species, especially M. alba, should be deeper studied for screening
potential candidates for future treatments.