ABO-Incompatible Liver Transplantation: State of Art and Future Perspectives

Author(s): Chih-Hsien Cheng*, Chen-Fang Lee, Yu-Chao Wang, Tsung-Han Wu, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan, Wei-Chen Lee

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 28 , 2020

DOI : 10.2174/1381612826666200506094539

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Abstract:

ABO-incompatible (ABO-I) liver transplantation (LT) has been limited due to the increased rate of complications, including severe cellular and antibody-mediated rejection, hepatic necrosis, hepatic artery thrombosis, and biliary complications. However, several strategies for reducing preformed anti-donor ABO antibodies and B cell desensitization have improved the outcomes of ABO-I LT. As a result, ABO-I LT has become a routine procedure and is a feasible option in countries with a scarce deceased-organ donation or in cases without an available compatible organ donor. In this review, we describe past and present desensitizing protocols as well as emergent therapies for depleting B cell and anti-ABO antibodies with the objective of identifying approaches that could lead to new, refined strategies for maximizing the results of ABO-I LT.

Keywords: ABO, incompatible, liver, transplantation, desensitization, isoagglutinin titer, rituximab, plasmapheresis.

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VOLUME: 26
ISSUE: 28
Year: 2020
Published on: 31 August, 2020
Page: [3406 - 3417]
Pages: 12
DOI: 10.2174/1381612826666200506094539
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