Physical Activity and Body Mass Index in Relation to Infertility in Women

Author(s): Chieko Kaneda, Yuji Kanejima, Masahiro Kitamura, Kazuhiro P. Izawa*

Journal Name: Reviews on Recent Clinical Trials

Volume 15 , Issue 3 , 2020

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Graphical Abstract:


Background: Infertility is a global social issue, and reproductive health is a priority in global health. This review aimed to study the relation between physical activity (PA) and infertility in non-obese or non-overweight women.

Methods: We used search strategies in the National Library of Medicine database including the PubMed database to October 2019 to find articles related to women and fertility, infertility, exercise, PA, pregnancy rate, live births, fecundability, and conception. Only cohort studies or randomized controlled trials in English were chosen for review that included outcomes directly related to becoming pregnant. We selected studies in which the participants were categorized by low or high body mass index (BMI).

Results: We found 6 papers meeting our criteria. In the association between PA and outcome, vigorous PA in women with low BMI resulted in both positive and negative effects that were weaker than those in women with high BMI. Among women with low BMI, moderate PA was weakly but positively associated with outcome whereas walking was not.

Conclusion: We observed some trends and a slight difference between the outcomes of women with low versus high BMI. There are only a few studies on infertile women with low BMI, and further investigation is warranted.

Keywords: Physical activity, exercise, infertility, fertility, pregnant, body mass index.

Loy SL, Cheung YB, Soh SE, et al. Female adiposity and time- to-pregnancy: A multiethnic prospective cohort. Hum Reprod 2018; 33(11): 2141-9.
[] [PMID: 30285230]
Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: A systematic analysis of 277 health surveys. PLoS Med 2012; 9(12): e1001356.
[] [PMID: 23271957]
Rooney KL, Domar AD. The impact of lifestyle behaviors on infertility treatment outcome. Curr Opin Obstet Gynecol 2014; 26(3): 181-5.
[] [PMID: 24752004]
Sharma R, Biedenharn KR, Fedor JM, Agarwal A. Lifestyle factors and reproductive health: Taking control of your fertility. Reprod Biol Endocrinol 2013; 11: 66.
[] [PMID: 23870423]
Kudesia R, Wu H, Hunter Cohn K, et al. The effect of female body mass index on in vitro fertilization cycle outcomes: A multi- center analysis. J Assist Reprod Genet 2018; 35(11): 2013-23.
[] [PMID: 30132171]
Wang HH, Cui Q, Zhang T, et al. Removal of mouse ovary fat pad affects sex hormones, folliculogenesis and fertility. J Endocrinol 2017; 232(2): 155-64.
[] [PMID: 27821469]
Rich-Edwards JW, Spiegelman D, Garland M, et al. Physical activity, body mass index, and ovulatory disorder infertility. Epidemiology 2002; 13(2): 184-90.
[] [PMID: 11880759]
Best D, Avenell A, Bhattacharya S. How effective are weight-loss interventions for improving fertility in women and men who are overweight or obese? A systematic review and meta-analysis of the evidence. Hum Reprod Update 2017; 23(6): 681-705.
[] [PMID: 28961722]
Lee J. Determining the association between physical activity prior to conception and pregnancy rate: A systematic review and meta-analysis of prospective cohort studies. Health Care Women Int 2019; 24: 1-16.
[] [PMID: 31339829]
Mena GP, Mielke GI, Brown WJ. The effect of physical activity on reproductive health outcomes in young women: A systematic review and meta-analysis. Hum Reprod Update 2019; 25(5): 541-63.
[] [PMID: 31304974]
National Institute of Population and Social Security Research Tokyo, Japan [Internet]. The Fifteenth Japanese National Fertility Survey, 2015 (Results of Singles and Married Couples Survey), 2015. Available Online:
Outline of the National Health and Nutrition Survey Results [Internet]. Ministry of Health and Labour and Welfare of Japan, c2018-12 Available online:
Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med 2009; 6(7): e1000100.
[] [PMID: 19621070]
McKinnon CJ, Hatch EE, Rothman KJ, et al. Body mass index, physical activity and fecundability in a North American preconception cohort study. Fertil Steril 2016; 106(2): 451-9.
[] [PMID: 27125230]
Morris SN, Missmer SA, Cramer DW, Powers RD, McShane PM, Hornstein MD. Effects of lifetime exercise on the outcome of in vitro fertilization. Obstet Gynecol 2006; 108(4): 938-45.
[] [PMID: 17012457]
Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstet Gynecol 2007; 110(5): 1050-8.
[] [PMID: 17978119]
Wise LA, Rothman KJ, Mikkelsen EM, Sørensen HT, Riis AH, Hatch EE. A prospective cohort study of physical activity and time to pregnancy. Fertil Steril 2012; 97(5): 1136-42.e1, 4.
[] [PMID: 22425198]
Russo LM, Whitcomb BW, Mumford SL, et al. A prospective study of physical activity and fecundability in women with a history of pregnancy loss. Hum Reprod 2018; 33(7): 1291-8.
[] [PMID: 29648647]
Takeda S, Tanaka A, Kuroda K. Treatment for infertility and recurrent miscarriage on the basis of clinical data. Best practice guide in infertility clinic for realizing parent’s hopes. Medical View 2017; 1: 64-86.
Hakimi O, Cameron LC. Effect of exercise on ovulation: A systematic review. Sports Med 2017; 47(8): 1555-67.
[] [PMID: 28035585]
Gudmundsdottir SL, Flanders WD, Augestad LB. Physical activity and fertility in women: The North-Trøndelag Health Study. Hum Reprod 2009; 24(12): 3196-204.
[] [PMID: 19801570]
Oguri T. HEALTH MANAGEMENT I: Relationship among BMI, percent body fat mass (%BF) and consciousness investigation for Bunkyo Women’s University. J Bunkyo Women’s Univ 1999; 1: 237-56.
Diamanti-Kandarakis E, Bergiele A. The influence of obesity on hyperandrogenism and infertility in the female. Obes Rev 2001; 2(4): 231-8.
[] [PMID: 12119994]
Talmor A, Dunphy B. Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol 2015; 29(4): 498-506.
[] [PMID: 25619586]
Palomba S, Giallauria F, Falbo A, et al. Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: A 24-week pilot study. Hum Reprod 2008; 23(3): 642-50.
[] [PMID: 18158291]

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Article Details

Year: 2020
Published on: 21 September, 2020
Page: [199 - 204]
Pages: 6
DOI: 10.2174/1574887115666200506091936
Price: $65

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