Pharmacological and Therapeutic Aspects of Plants from the Genus Ferula: A Comprehensive Review

Author(s): Mohammad Sabzehzari, Mohammad Reza Naghavi, Motahare Bozari, Hossein M. Orafai, Thomas P. Johnston, Amirhossein Sahebkar*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 13 , 2020


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Inspired by nature, humankind has been able to attain significant achievements in the drug and food industries. Particularly, medicinal plants are a rich source of medicinal, cosmetic, sanitary, and aromatic substances. Genus Ferula from the Apiaceae family is a plant genus that possesses over 170 species, which have been carefully documented with regard to their medicinal properties. Ferula spp. affects many body organs, and their respective functions, in humans, such as the immune system, gastrointestinal tract, genitourinary, endocrine, respiratory, cardiovascular, nervous system, bone (skeleton), and teeth. In spite of the benefits, ferulosis (Ferula toxicity) is an important aspect of Ferula consumption in humans and animals. Hemorrhagic problems and infertility are important signs of ferulosis. In this review, we have described all of the effects of the active ingredients of Ferula spp. and their mechanisms of actions, when known, based on an extensive literature review. Thus, our review opens a window of the benefits of Ferula as a phyto-pharmaceutical and its therapeutic applications in pharmacy, dentistry, and medicine.

Keywords: Ferula, phytomedicine, pharmacy, dentistry, medicine, phyto-pharmaceutical.

[1]
Jeelani, S.M.; Rather, G.A.; Sharma, A.; Lattoo, S.K. In perspective: Potential medicinal plant resources of Kashmir Himalayas, their domestication and cultivation for commercial exploitation. J. Applied Res. Med. Aroma. Plants, 2018, 8, 10-25.
[http://dx.doi.org/10.1016/j.jarmap.2017.11.001]
[2]
Abd El-Razek, M.H.; Ohta, S.; Hirata, T. Terpenoid coumarins of the genus Ferula. Heterocycles, 2003, 60, 689-716.
[http://dx.doi.org/10.3987/REV-02-561]
[3]
Panahi, M. Banasiak ł, Piwczyński M, Puchałka R, Kanani MR, Oskolski AA, Modnicki D, Miłobędzka A, Spalik K. Taxonomy of the traditional medicinal plant genus Ferula (Apiaceae) is confounded by incongruence between nuclear rDNA and plastid DNA. Bot. J. Linn. Soc., 2018, 188, 173-189.
[http://dx.doi.org/10.1093/botlinnean/boy055]
[4]
Mozaffarian, V. A Dictionary of Iranian Plant Names; Farhang-e Moaser, 1996, pp. 228-230.
[5]
Mohammadhosseini, M.; Venditti, A.; Sarker, S.D.; Nahar, L.; Akbarzadeh, A. The genus Ferula: Ethnobotany, phytochemistry and bioactivities–A review. Ind. Crops Prod., 2019, 129, 350-394.
[http://dx.doi.org/10.1016/j.indcrop.2018.12.012]
[6]
Moghaddam, M.; Farhadi, N. Influence of environmental and genetic factors on resin yield, essential oil content and chemical composition of Ferula assa-foetida L. populations. J. Applied Res. Med. Aroma. Plants, 2015, 2, 69-76.
[http://dx.doi.org/10.1016/j.jarmap.2015.04.001]
[7]
Kouyakhi, E.T.; Naghavi, M.; Alayhs, M. Study of the essential oil variation of Ferula gummosa samples from Iran. Chem. Nat. Compd., 2008, 44, 124-126.
[http://dx.doi.org/10.1007/s10600-008-0038-4]
[8]
Sahebkar, A.; Iranshahi, M. Volatile constituents of the genus Ferula (Apiaceae): A review. J. Essent. Oil Bearing Plants, 2011, 14, 504-531.
[http://dx.doi.org/10.1080/0972060X.2011.10643969]
[9]
Najafabadi, A.S.; Naghavi, M.R.; Farahmand, H.; Abbasi, A.R.; Yazdanfar, N. Chemical composition of the essential oil from oleo-gum-resin and different organs of Ferula gummosa. J. Essent. Oil Bearing Plants, 2017, 20, 282-288.
[http://dx.doi.org/10.1080/0972060X.2016.1263582]
[10]
Iranshahi, M.; Rezaee, R.; Najaf Najafi, M.; Haghbin, A.; Kasaian, J. Cytotoxic activity of the genus Ferula (Apiaceae) and its bioactive constituents. Avicenna J. Phytomed., 2018, 8(4), 296-312.
[PMID: 30377589]
[11]
Sobhani Najafabadi, A.; Naghavi, M.R. Mining Ferula gummosa transcriptome to identify miRNAs involved in the regulation and biosynthesis of terpenes. Gene, 2018, 645, 41-47.
[http://dx.doi.org/10.1016/j.gene.2017.12.035] [PMID: 29273556]
[12]
Amer, A.; Mehlhorn, H. Larvicidal effects of various essential oils against Aedes, Anopheles, and Culex larvae (Diptera, Culicidae). Parasitol. Res., 2006, 99(4), 466-472.
[http://dx.doi.org/10.1007/s00436-006-0182-3] [PMID: 16642386]
[13]
Kanani, M.R.; Rahiminejad, M.R.; Sonboli, A.; Mozaffarian, V.; Kazempour Osaloo, S.; Nejad Ebrahimi, S. Chemotaxonomic significance of the essential oils of 18 Ferula species (Apiaceae) from Iran. Chem. Biodivers., 2011, 8(3), 503-517.
[http://dx.doi.org/10.1002/cbdv.201000148] [PMID: 21404434]
[14]
Seki, Y.; Sarikanat, M.; Sever, K.; Durmuşkahya, C. Extraction and properties of Ferula communis (chakshir) fibers as novel reinforcement for composites materials. Compos., Part B Eng., 2013, 44, 517-523.
[http://dx.doi.org/10.1016/j.compositesb.2012.03.013]
[15]
Behpour, M.; Ghoreishi, S.M.; Khayat Kashani, M.; Soltan, N. Inhibition of 304 stainless steel corrosion in acidic solution by Ferula gumosa (galbanum) extract. Materials and Corrosion, 2009, 60, 895-898.
[http://dx.doi.org/10.1002/maco.200905182]
[16]
Nasiri, J.; Rahimi, M.; Hamezadeh, Z.; Motamedi, E.; Naghavi, M.R. Fulfillment of green chemistry for synthesis of silver nanoparticles using root and leaf extracts of Ferula persica: Solid-state route vs. solution-phase method. J. Clean. Prod., 2018, 192, 514-530.
[http://dx.doi.org/10.1016/j.jclepro.2018.04.218]
[17]
Polycarpou, P. Ethanol production from Ferula communis. Biomass Bioenergy, 2012, 36, 289-292.
[http://dx.doi.org/10.1016/j.biombioe.2011.10.039]
[18]
Nazari, Z.E.; Iranshahi, M. Biologically active sesquiterpene coumarins from Ferula species. Phytother. Res., 2011, 25(3), 315-323.
[PMID: 21031633]
[19]
Sahebkar, A.; Iranshahi, M. Biological activities of essential oils from the genus Ferula (Apiaceae). Asian Biomed., 2010, 4, 835-847.
[http://dx.doi.org/10.2478/abm-2010-0110]
[20]
Lee, C.L.; Chiang, L.C.; Cheng, L.H.; Liaw, C.C.A.E-R.; Abd El-Razek, M.H.; Chang, F.R.; Wu, Y.C.M.H.; Chang, FR.; Wu, Y.C. Influenza A (H1N1) antiviral and cytotoxic agents from Ferula assafoetida. J. Nat. Prod., 2009, 72(9), 1568-1572.
[http://dx.doi.org/10.1021/np900158f] [PMID: 19691312]
[21]
Eskandani, M.; Abdolalizadeh, J.; Hamishehkar, H.; Nazemiyeh, H.; Barar, J. Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells. Fitoterapia, 2015, 101, 1-11. b
[http://dx.doi.org/10.1016/j.fitote.2014.12.003] [PMID: 25510323]
[22]
Lee, T.T.; Kashiwada, Y.; Huang, L.; Snider, J.; Cosentino, M.; Lee, K.H.; Lee, K.H. Suksdorfin: An anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides. Bioorg. Med. Chem., 1994, 2(10), 1051-1056.
[http://dx.doi.org/10.1016/S0968-0896(00)82054-4] [PMID: 7773621]
[23]
Gustafson, K.R.; Cardellina, J.H., II; McMahon, J.B.; Gulakowski, R.J.; Ishitoya, J.; Szallasi, Z.; Lewin, N.E.; Blumberg, P.M.; Weislow, O.S.; Beutler, J.A.; Buckheit, R.W., Jr; Cragg, G.M.; Cox, P.A.; Barder, J.P.; Boyd, M.R. A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J. Med. Chem., 1992, 35(11), 1978-1986.
[http://dx.doi.org/10.1021/jm00089a006] [PMID: 1597853]
[24]
Fujioka, T.; Kashiwada, Y.; Kilkuskie, R.E.; Cosentino, L.M.; Ballas, L.M.; Jiang, J.B.; Janzen, W.P.; Chen, I.S.; Lee, K.H. Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J. Nat. Prod., 1994, 57(2), 243-247.
[http://dx.doi.org/10.1021/np50104a008] [PMID: 8176401]
[25]
Zhou, P.; Takaishi, Y.; Duan, H.; Chen, B.; Honda, G.; Itoh, M.; Takeda, Y.; Kodzhimatov, O.K.; Lee, K.H. Coumarins and bicoumarin from Ferula sumbul: Anti-HIV activity and inhibition of cytokine release. Phytochemistry, 2000, 53(6), 689-697.
[http://dx.doi.org/10.1016/S0031-9422(99)00554-3] [PMID: 10746882]
[26]
Jahansooz, F.; Ebrahimzadeh, H.; Najafi, A.A.; Naghavi, M.R.; Talebi-Kouyakhi, E.; Farzaneh, H. Composition and antifungal activity of the oil of Ferula gummosa samples from Iran. J. Essent. Oil Bearing Plants, 2008, 11, 284-291.
[http://dx.doi.org/10.1080/0972060X.2008.10643632]
[27]
Divya, K.; Ramalakshmi, K.; Murthy, P.S.; Rao, L.J.M. Volatile oils from Ferula asafoetida varieties and their antimicrobial activity. Lebensm. Wiss. Technol., 2014, 59, 774-779.
[http://dx.doi.org/10.1016/j.lwt.2014.07.013]
[28]
Zangoie, M.; Parsa, S.; Jahani, M.; Mahmoodi, S. Antifungal effects of assafoetida seed essential oil on in vitro growth of five species of plant pathogenic fungi. Int. Res. J. Appl. Basic Sci., 2013, 4, 1159-1162.
[29]
Zomorodian, K.; Saharkhiz, J.; Pakshir, K.; Immeripour, Z.; Sadatsharifi, A. The composition, antibiofilm and antimicrobial activities of essential oil of Ferula assafoetida oleo-gum-resin. Biocatal. Agric. Biotechnol., 2018, 14, 300-304.
[http://dx.doi.org/10.1016/j.bcab.2018.03.014]
[30]
Al-Ja’fari, A.H.; Vila, R.; Freixa, B.; Costa, J.; Cañigueral, S. Antifungal compounds from the rhizome and roots of Ferula hermonis. Phytother. Res., 2013, 27(6), 911-915.
[http://dx.doi.org/10.1002/ptr.4806] [PMID: 22927102]
[31]
Iranshahi, M.; Kalategi, F.; Rezaee, R.; Shahverdi, A.R.; Ito, C.; Furukawa, H.; Tokuda, H.; Itoigawa, M. Cancer chemopreventive activity of terpenoid coumarins from Ferula species. Planta Med., 2008, 74(2), 147-150.
[http://dx.doi.org/10.1055/s-2008-1034293] [PMID: 18240102]
[32]
Rao, A.; Zhang, Y.; Muend, S.; Rao, R. Mechanism of antifungal activity of terpenoid phenols resembles calcium stress and inhibition of the TOR pathway. Antimicrob. Agents Chemother., 2010, 54(12), 5062-5069.
[http://dx.doi.org/10.1128/AAC.01050-10] [PMID: 20921304]
[33]
Ahmad, A.; Khan, A.; Akhtar, F.; Yousuf, S.; Xess, I.; Khan, L.A.; Manzoor, N. Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida. Eur. J. Clin. Microbiol. Infect. Dis., 2011, 30(1), 41-50.
[http://dx.doi.org/10.1007/s10096-010-1050-8] [PMID: 20835742]
[34]
Odhav, B.; Juglal, S.; Govinden, R. Spices Oliz for the control of co-occurring mycotoxins producing fungi. Eur. Food Res. Technol., 2002, 65, 683-687.
[35]
Cox, S.D.; Mann, C.M.; Markham, J.L.; Bell, H.C.; Gustafson, J.E.; Warmington, J.R.; Wyllie, S.G. The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil). J. Appl. Microbiol., 2000, 88(1), 170-175.
[http://dx.doi.org/10.1046/j.1365-2672.2000.00943.x] [PMID: 10735256]
[36]
Silva, J.P.; de Nascimento, S.C.; Okabe, D.H.; Pinto, A.C.; de Oliveira, F.R.; da Paixão, T.P.; Siqueira, M.L.; Baetas, A.C.; de Andrade, M.A. Antimicrobial and anticancer potential of Petiveria alliacea L. (Herb to “Tame the Master”): A review. Pharmacogn. Rev., 2018, 12, 85-93.
[http://dx.doi.org/10.1590/S0102-695X2002000300042]
[37]
Kahraman, C.; Topcu, G.; Bedir, E.; Tatli, I.I.; Ekizoglu, M.; Akdemir, Z.S. Phytochemical screening and evaluation of the antimicrobial and antioxidant activities of Ferula caspica M. Bieb. extracts. Saudi Pharm. J., 2019, 27(4), 525-531.
[http://dx.doi.org/10.1016/j.jsps.2019.01.016] [PMID: 31061621]
[38]
Kavoosi, G.; Tafsiry, A.; Ebdam, A.A.; Rowshan, V. Evaluation of antioxidant and antimicrobial activities of essential oils from Carum copticum seed and Ferula assafoetida latex. J. Food Sci., 2013, 78(2), T356-T361.
[http://dx.doi.org/10.1111/1750-3841.12020] [PMID: 23320824]
[39]
Burt, S. Essential oils: Their antibacterial properties and potential applications in foods--a review. Int. J. Food Microbiol., 2004, 94(3), 223-253.
[http://dx.doi.org/10.1016/j.ijfoodmicro.2004.03.022] [PMID: 15246235]
[40]
Sharma, P.C.; Jain, S.; Yadav, G.; Sharma, A. Natural preservatives: current insights and applications. Pharm. Sin., 2010, 1, 95-108.
[41]
Emiroğlu, Z.K.; Yemiş, G.P.; Coşkun, B.K.; Candoğan, K. Antimicrobial activity of soy edible films incorporated with thyme and oregano essential oils on fresh ground beef patties. Meat Sci., 2010, 86(2), 283-288.
[http://dx.doi.org/10.1016/j.meatsci.2010.04.016] [PMID: 20580990]
[42]
Oussalah, M.; Caillet, S.; Saucier, L.; Lacroix, M. Inhibitory effects of selected plant essential oils on the growth of four pathogenic bacteria: E. coli O157:H7, S. typhimurium, S. aureus and Listeria monocytogenes. Food Control, 2007, 18, 414-420.
[http://dx.doi.org/10.1016/j.foodcont.2005.11.009]
[43]
Xu, J.; Zhou, F.; Ji, B.P.; Pei, R.S.; Xu, N. The antibacterial mechanism of carvacrol and thymol against Escherichia coli. Lett. Appl. Microbiol., 2008, 47(3), 174-179.
[http://dx.doi.org/10.1111/j.1472-765X.2008.02407.x] [PMID: 19552781]
[44]
Singh, C.; Parmar, R. Antimicrobial activity of resin of asafoetida (Hing) against certain human pathogenic bacteria. Adv. Biores., 2018, 9, 161-164.
[45]
Appendino, G.; Mercalli, E.; Fuzzati, N.; Arnoldi, L.; Stavri, M.; Gibbons, S.; Ballero, M.; Maxia, A. Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis). J. Nat. Prod., 2004, 67(12), 2108-2110.
[http://dx.doi.org/10.1021/np049706n] [PMID: 15620264]
[46]
Satarian, F.; Hosseini, H.M.; Ghadaksaz, A.; Amin, M.; Fooladi, A.A.I. Ferula gummosa Boiss inhibits Multi drug resistant clinical Pseudomonas aeruginosas. Rec. Pat. Anti-Infect. Drug Disc., 2018, 13(1), 89-99.
[http://dx.doi.org/10.2174/1574891X13666180426163427]
[47]
García-García, R.; López-Malo, A.; Palou, E. Bactericidal action of binary and ternary mixtures of carvacrol, thymol, and eugenol against Listeria innocua. J. Food Sci., 2011, 76(2), M95-M100.
[http://dx.doi.org/10.1111/j.1750-3841.2010.02005.x] [PMID: 21535780]
[48]
Shahverdi, A.R.; Fakhimi, A.; Zarrini, G.; Dehghan, G.; Iranshahi, M. Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus; Biological and Pharmaceutical Sciences, 2007.
[http://dx.doi.org/10.1248/bpb.30.1805]
[49]
Adonizio, A.L.; Downum, K.; Bennett, B.C.; Mathee, K. Anti-quorum sensing activity of medicinal plants in southern Florida. J. Ethnopharmacol., 2006, 105(3), 427-435.
[http://dx.doi.org/10.1016/j.jep.2005.11.025] [PMID: 16406418]
[50]
Schonewille, E. L.L. N.; Hauck, R.; Windhorst, D.; Hafez, HM.; Vestby, LK. Biofilm building capacity of Salmonella enterica strains from the poultry farm environment. FEMS Immunol. J. Med. Microbiol., 2012, 65, 360-365.
[51]
Sepahi, E.; Tarighi, S.; Ahmadi, F.S.; Bagheri, A. Inhibition of quorum sensing in Pseudomonas aeruginosa by two herbal essential oils from Apiaceae family. J. Microbiol., 2015, 53(2), 176-180.
[http://dx.doi.org/10.1007/s12275-015-4203-8] [PMID: 25564444]
[52]
Hong, K.W.; Koh, C.L.; Sam, C.K.; Yin, W.F.; Chan, K.G. Quorum quenching revisited--from signal decays to signalling confusion. Sensors (Basel), 2012, 12(4), 4661-4696.
[http://dx.doi.org/10.3390/s120404661] [PMID: 22666051]
[53]
Dehpour, A.A.; Ebrahimzadeh, M.A.; Fazel, N.S.; Mohammad, N.S. Antioxidant activity of the methanol extract of Ferula assafoetida and its essential oil composition. Grasas Aceites, 2009, 60, 405-412.
[http://dx.doi.org/10.3989/gya.010109]
[54]
Rahali, F.Z.; Kefi, S.; Bettaieb, R.I.; Hamdaoui, G.; Tabart, J.; Kevers, C.; Franck, T.; Mouithys-Mickalad, A.; Hamrouni-Sellami, I. Phytochemical composition and antioxidant activities of different aerial parts extracts of Ferula communis. Plant Biosyst., 2019, 153(2), 213-221.
[55]
Nazari, A.; Golezar, E.; Mahdiuni, H. Antioxidant activity of the Ferula gummosa Boiss.'s aerial parts: Measurements based on different assay methods. J. Reports Pharmaceut. Sci., 2019, 8, 61.
[http://dx.doi.org/10.4103/jrptps.jrptps_12_19]
[56]
Beutler, B. Innate immunity: An overview. Mol. Immunol., 2004, 40(12), 845-859.
[http://dx.doi.org/10.1016/j.molimm.2003.10.005] [PMID: 14698223]
[57]
Witko-Sarsat, V.; Rieu, P.; Descamps-Latscha, B.; Lesavre, P.; Halbwachs-Mecarelli, L. Neutrophils: Molecules, functions and pathophysiological aspects. Lab. Invest., 2000, 80(5), 617-653.
[http://dx.doi.org/10.1038/labinvest.3780067] [PMID: 10830774]
[58]
Su, Y.; Richmond, A. Chemokine regulation of neutrophil infiltration of skin wounds. Adv. Wound Care (New Rochelle), 2015, 4(11), 631-640.
[http://dx.doi.org/10.1089/wound.2014.0559] [PMID: 26543677]
[59]
Schepetkin, I.A.; Kirpotina, L.N.; Khlebnikov, A.I.; Quinn, M.T. High-throughput screening for small-molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists. Mol. Pharmacol., 2007, 71(4), 1061-1074.
[http://dx.doi.org/10.1124/mol.106.033100] [PMID: 17229869]
[60]
Oüzek, G.; Schepetkin, I.A.; Utegenova, G.A.; Kirpotina, L.N.; Andrei, T.; Sr, O.; Can-Baser, KH.; Abidkulova, KT.; Kushnarenko, SV.; Khlebnikov, AI.; Damron, DS.; Quinn, MT. Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils. J. Leukoc. Biol., 2017, 101, 1361-1371.
[http://dx.doi.org/10.1189/jlb.3A1216-518RR]
[61]
Appendino, G.; Maxia, L.; Bascope, M.; Houghton, P.J.; Sanchez-Duffhues, G.; Muñoz, E.; Sterner, O. A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida. J. Nat. Prod., 2006, 69(7), 1101-1104.
[http://dx.doi.org/10.1021/np0600954] [PMID: 16872156]
[62]
Ardizzone, S.; Bianchi Porro, G. Biologic therapy for inflammatory bowel disease. Drugs, 2005, 65(16), 2253-2286.
[http://dx.doi.org/10.2165/00003495-200565160-00002] [PMID: 16266194]
[63]
Shahverdi, A.R.; Saadat, F.; Khorramizadeh, M.R.; Iranshahi, M.; Khoshayand, M.R. Two matrix metalloproteinases inhibitors from Ferula persica var. persica. Phytomedicine, 2006, 13(9-10), 712-717.
[http://dx.doi.org/10.1016/j.phymed.2006.01.003] [PMID: 16487689]
[64]
Askari, V.R.; Baradaran Rahimi, V.; Assaran, A.; Iranshahi, M.; Boskabady, M.H. Evaluation of the anti-oxidant and anti-inflammatory effects of the methanolic extract of Ferula szowitsiana root on PHA-induced inflammation in human lymphocytes. Drug Chem. Toxicol., 2019, 1-8.
[http://dx.doi.org/10.1080/01480545.2019.1572182] [PMID: 30764672]
[65]
Sadoughi, S.D. Effect of aqueous extract of Ferula asafoetida’s resin on wound healing of Streptozotocin induced diabetic rats. Quart. Horizon Med. Sci., 2013, 19, 129-135.
[66]
Sacchetti, G.; Appendino, G.; Ballero, M.; Loy, C.; Poli, F. Vittae fluorescence as a tool to differentiate between poisonous and non-poisonous populations of giant fennel (Ferula communis) of the island Sardinia (Italy). Biochem. Syst. Ecol., 2003, 31, 527-534.
[http://dx.doi.org/10.1016/S0305-1978(02)00199-0]
[67]
Appendino, G.; Cravotto, G.; Sterner, O.; Ballero, M. Oxygenated sesquiterpenoids from a nonpoisonous sardinian chemotype of giant fennel (Ferula communis). J. Nat. Prod., 2001, 64(3), 393-395.
[http://dx.doi.org/10.1021/np000468f] [PMID: 11277767]
[68]
Rubiolo, P.; Matteodo, M.; Riccio, G.; Ballero, M.; Christen, P.; Fleury-Souverain, S.; Veuthey, J.L.; Bicchi, C. Analytical discrimination of poisonous and nonpoisonous chemotypes of giant fennel (Ferula communis L.) through their biologically active and volatile fractions. J. Agric. Food Chem., 2006, 54(20), 7556-7563.
[http://dx.doi.org/10.1021/jf061592t] [PMID: 17002421]
[69]
Li, T.; Chang, C.Y.; Jin, D.Y.; Lin, P.J.; Khvorova, A.; Stafford, D.W. Identification of the gene for vitamin K epoxide reductase. Nature, 2004, 427(6974), 541-544.
[http://dx.doi.org/10.1038/nature02254] [PMID: 14765195]
[70]
Louvet, M.S.; Gault, G.; Lefebvre, S.; Popowycz, F.; Boulven, M.; Besse, S.; Benoit, E.; Lattard, V.; Grancher, D. Comparative inhibitory effect of prenylated coumarins, ferulenol and ferprenin, contained in the ‘poisonous chemotype’ of Ferula communis on mammal liver microsomal VKORC1 activity. Phytochemistry, 2015, 118, 124-130.
[http://dx.doi.org/10.1016/j.phytochem.2015.08.012] [PMID: 26314757]
[71]
Oldenburg, J.; Marinova, M.; Müller-Reible, C.; Watzka, M. The vitamin K cycle. Vitam. Horm., 2008, 78, 35-62.
[http://dx.doi.org/10.1016/S0083-6729(07)00003-9] [PMID: 18374189]
[72]
Kumar, D.; Kumar, A.; Prakash, O. Potential antifertility agents from plants: A comprehensive review. J. Ethnopharmacol., 2012, 140(1), 1-32.
[http://dx.doi.org/10.1016/j.jep.2011.12.039] [PMID: 22245754]
[73]
Zavatti, M.; Montanari, C.; Zanoli, P. Role of ferutinin in the impairment of female sexual function induced by Ferula hermonis. Physiol. Behav., 2006, 89(5), 656-661.
[http://dx.doi.org/10.1016/j.physbeh.2006.08.002] [PMID: 16970966]
[74]
Homady, M.H.; Khleifat, K.M.; Tarawneh, K.A.; Al-Raheil, I.A. Reproductive toxicity and infertility effect of Ferula hornonis extracts in mice. Theriogenology, 2002, 57(9), 2247-2256.
[http://dx.doi.org/10.1016/S0093-691X(02)00900-7] [PMID: 12141574]
[75]
Keshri, G.; Lakshmi, V.; Singh, M.M.; Kamboj, V.P. Post-coital antifertility activity of Ferula assafoetida extract in female rats. Pharm. Biol., 1999, 37, 273-276.
[http://dx.doi.org/10.1076/phbi.37.4.273.5806]
[76]
Ho, C.C.; Tan, H.M. Rise of herbal and traditional medicine in erectile dysfunction management. Curr. Urol. Rep., 2011, 12(6), 470-478.
[http://dx.doi.org/10.1007/s11934-011-0217-x] [PMID: 21948222]
[77]
El-Thaher, T.S.; Matalka, K.Z.; Taha, H.A.; Badwan, A.A. Ferula harmonis ‘zallouh’ and enhancing erectile function in rats: Efficacy and toxicity study. Int. J. Impot. Res., 2001, 13(4), 247-251.
[http://dx.doi.org/10.1038/sj.ijir.3900706] [PMID: 11494083]
[78]
Hadidi, K.A.; Aburjai, T.; Battah, A.K. A comparative study of Ferula hermonis root extracts and sildenafil on copulatory behaviour of male rats. Fitoterapia, 2003, 74(3), 242-246.
[http://dx.doi.org/10.1016/S0367-326X(03)00032-7] [PMID: 12727488]
[79]
Zanoli, P.; Rivasi, M.; Zavatti, M.; Brusiani, F.; Vezzalini, F.; Baraldi, M. Activity of single components of Ferula hermonis on male rat sexual behavior. Int. J. Impot. Res., 2005, 17(6), 513-518.
[http://dx.doi.org/10.1038/sj.ijir.3901346] [PMID: 15920458]
[80]
Kassis, E.; Fulder, S.; Khalil, K.; Hadieh, B.; Nahhas, F.; Saad, B.; Said, O. Efficacy and safety assessments of Ferula assa-foetida L. traditionally used in Greco-Arab herbal medicine for enhancing male fertility, libido and erectile function. Open Complement. Med. J., 2009, 1, 102-109.
[81]
Eser, N.; Buyuknacar, H.S.; Cimentepe, O.O.; Gocmen, C.; Ucar, Y.; Erdogan, S.; Yoshiyama, M. The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat. Int. J. Impot. Res., 2020, 32(2), 186-194.
[http://dx.doi.org/10.1038/s41443-019-0137-8] [PMID: 30979969]
[82]
Sundararajan, R.; Bharampuram, A.; Koduru, R. A review on phytoconstituents for nephroprotective activity. Pharmacophore, 2014, 5, 160-182.
[83]
Javaid, R.; Aslam, M.; Javaid, R.; Nizami, Q.; Javed, K.; Azhar, M.U. Extract of Ferula foetida regel reverses gentamicin-induced nephrotoxicity in rats. EXCLI J., 2012, 11, 760-766.
[PMID: 27847458]
[84]
Prasad, K.; Sujatha, D.; Bharathi, K. Herbal drugs in urolithiasis-a review. Pharmacogn. Rev., 2007, 1, 175-179.
[85]
Bagheri, S.M.; Yadegari, M.; Behpur, M.; Javidmehr, D. Antilithiatic and hepatoprotective effects of Ferula assa-foetida oleo-gum-resin on ethylene glycol-induced lithiasis in rats. Urol. Sci., 2018, 29, 180-185.
[http://dx.doi.org/10.4103/UROS.UROS_10_18]
[86]
Wyatt, S.B.; Winters, K.P.; Dubbert, P.M. Overweight and obesity: prevalence, consequences, and causes of a growing public health problem. Am. J. Med. Sci., 2006, 331(4), 166-174.
[http://dx.doi.org/10.1097/00000441-200604000-00002] [PMID: 16617231]
[87]
Azizian, H.; Rezvani, M.E.; Esmaeilidehaj, M.; Bagheri, S.M. Anti-Obesity, fat lowering and liver steatosis protective effects of Ferula asafoetida Gum in Type 2 Diabetic Rats: Possible involvement of leptin. Iran. J. Diabetes Obes., 2012, 4, 120-126.
[88]
Zhang, B.B.; Moller, D.E. New approaches in the treatment of type 2 diabetes. Curr. Opin. Chem. Biol., 2000, 4(4), 461-467.
[http://dx.doi.org/10.1016/S1367-5931(00)00103-4] [PMID: 10959776]
[89]
Akhlaghi, F.; Rajaei, Z.; Hadjzadeh, M.; Iranshahi, M.; Alizadeh, M. Antihyperglycemic effect of asafoetida (Ferula assafoetida oleo-gum-resin) in streptozotocininduced diabetic rats. World Appl. Sci. J., 2012, 17, 157-162.
[90]
Abu-Zaiton, A.S. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pak. J. Biol. Sci., 2010, 13(2), 97-100.
[http://dx.doi.org/10.3923/pjbs.2010.97.100] [PMID: 20415145]
[91]
Helal, E.G.E.; Mostafa, A.M.; Mahmood, A.F.; Kahwash, A.A. Hypoglycemic and hyperinsulinemic effects of Ferula asafoetida on diabetic male albino rats. Egyp. J. Hosp. Med., 2005, 21, 95-108.
[92]
Choudhary, I.; Irfan-Baig, M.; Nur-e-Alm, M.; Shahzad‐ul‐Hussan, S.; Öndognii, P.; Bunderya, M.; Oyun, Z.; Atta‐ur‐Rahman, A. New a-glucosidase inhibitors from the Mongolian medicinal plant Ferula mongolica. Helv. Chim. Acta, 2001, 84, 2409-2416.
[http://dx.doi.org/10.1002/1522-2675(20010815)84:8<2409:AID-HLCA2409>3.0.CO;2-D]
[93]
Bischoff, H. Pharmacology of alpha-glucosidase inhibition. Eur. J. Clin. Invest., 1994, 24(3), 3-10.
[PMID: 8001624]
[94]
Latifi, E.; Mohammadpour, A.A. H, B.F.; Nourani, H. Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats. Biomed. Pharmacother., 2019, 110, 197-202.
[http://dx.doi.org/10.1016/j.biopha.2018.10.152] [PMID: 30471513]
[95]
Salmeen, A.; Andersen, J.N.; Myers, M.P.; Tonks, N.K.; Barford, D. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol. Cell, 2000, 6(6), 1401-1412.
[http://dx.doi.org/10.1016/S1097-2765(00)00137-4] [PMID: 11163213]
[96]
Tonks, N.K.; Muthuswamy, S.K. A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer. Cancer Cell, 2007, 11(3), 214-216.
[http://dx.doi.org/10.1016/j.ccr.2007.02.022] [PMID: 17349579]
[97]
Wulamu, S.; Yimamu, H.; Abuduwaili, A.; Mutailifu, P.; Maksimov, V.; Gao, Y.; Yili, A.; Aisa, H. Determination of the Inhibitory Activity of Ferula sinkiangensis Polysaccharides for Protein Tyrosine Phosphatase 1B. Chem. Nat. Compd., 2019, 55, 235-238.
[http://dx.doi.org/10.1007/s10600-019-02657-z]
[98]
Ghule, B.V.; Ghante, M.H.; Saoji, A.N.; Yeole, P.G. Hypolipidemic and antihyperlipidemic effects of Lagenaria siceraria (Mol.) fruit extracts. Indian J. Exp. Biol., 2006, 44(11), 905-909.
[PMID: 17205712]
[99]
Al-Awadi, F.; Shoukry, M. The lipid lowering effect of an anti-diabetic plant extract. Acta Diabetol. Lat., 1988, 25(1), 1-5.
[http://dx.doi.org/10.1007/BF02581239] [PMID: 3407374]
[100]
Bamoniri, A.; Mazoochi, A. Determination of bioactive and fragrant molecules from leaves and fruits of Ferula assafoetida L. growing in central Iran by nano scale injection. Dig. J. Nanomater. Biostruct., 2009, 4, 323-328.
[101]
Iranshahi, M.; Askari, M.; Sahebkar, A.; Hadjipavlou-Litina, D. Evaluation of antioxidant, anti-inflammatory and lipoxygenase inhibitory activities of the prenylated coumarin umbelliprenin. Daru, 2009, 17, 99-103.
[102]
Gholamnezhad, Z.; Byrami, G.; Boskabady, M.H.; Iranshahi, M. Possible mechanism (s) of the relaxant effect of asafoetida (Ferula asafoetida) oleo-gum-resin extract on guinea-pig tracheal smooth muscle. Avicenna J. Phytomed., 2012, 2, 10-16.
[103]
Mahmoody, S.A.; Gharakhanlou, R.; Roshan, V.D.; Hedayati, M. Individual and concomitant effects of cardioprotective programs on cardiac apelinergic system and oxidative state in L-NAME-induced hypertension. Clin. Exp. Hypertens., 2013, 35(1), 20-27.
[http://dx.doi.org/10.3109/10641963.2012.685536] [PMID: 22578103]
[104]
Morán, M.; Delgado, J.; González, B.; Manso, R.; Megías, A. Responses of rat myocardial antioxidant defences and heat shock protein HSP72 induced by 12 and 24-week treadmill training. Acta Physiol. Scand., 2004, 180(2), 157-166.
[http://dx.doi.org/10.1111/j.0001-6772.2003.01244.x] [PMID: 14738474]
[105]
Cecen, E.; Dost, T.; Culhaci, N.; Karul, A.; Ergur, B.; Birincioglu, M. Protective effects of silymarin against doxorubicin-induced toxicity. Asian Pac. J. Cancer Prev., 2011, 12(10), 2697-2704.
[PMID: 22320977]
[106]
Gholitabar, S.; Roshan, V.D. Effect of treadmill exercise and Ferula gummosa on myocardial HSP72, vascular function, and antioxidant defenses in spontaneously hypertensive rats. Clin. Exp. Hypertens., 2013, 35(5), 347-354.
[http://dx.doi.org/10.3109/10641963.2012.732643] [PMID: 23072319]
[107]
Mahendra, P.; Bisht, S. Ferula asafoetida: Traditional uses and pharmacological activity. Pharmacogn. Rev., 2012, 6(12), 141-146.
[http://dx.doi.org/10.4103/0973-7847.99948] [PMID: 23055640]
[108]
Pang, XX; Wang, X Research progress in tthrombosis and its mechanism. Med. Recapitulate, 2011, 17, 613-1-616.
[109]
Monti, M.; Pinotti, M.; Appendino, G.; Dallocchio, F.; Bellini, T.; Antognoni, F.; Poli, F.; Bernardi, F. Characterization of anticoagulant properties of prenylated coumarin ferulenol. Biochim. Biophys. Acta, 2007, 1770(10), 1437-1440.
[http://dx.doi.org/10.1016/j.bbagen.2007.06.013] [PMID: 17693024]
[110]
Sun, Z.L.; Liu, T.; Wang, S.Y.; Ji, X.Y.; Mu, Q. TLCbioautography directed isolation of antibacterial compounds from active fractionation of Ferula ferulioides. Nat. Prod. Res., 2019, 33(12), 1761-1764.
[PMID: 29378434]
[111]
Zargari, A. Medicinal Plants, 6th ed; Tehran University Publications, 1996.
[112]
Gundamaraju, R. Evaluation of anthelmintic activity of Ferula foetida “Hing- A natural Indian spice” aqueous extract. Asian Pac. J. Trop. Dis., 2013, 3, 189-191.
[http://dx.doi.org/10.1016/S2222-1808(13)60038-9]
[113]
Fatehi, M.; Farifteh, F.; Fatehi-Hassanabad, Z. Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. J. Ethnopharmacol., 2004, 91(2-3), 321-324.
[http://dx.doi.org/10.1016/j.jep.2004.01.002] [PMID: 15120456]
[114]
Pavlović, I.; Krunić, A.; Nikolić, D.; Radenković, M.; Branković, S.; Niketić, M.; Petrović, S. Chloroform extract of underground parts of Ferula heuffelii: Secondary metabolites and spasmolytic activity. Chem. Biodivers., 2014, 11(9), 1417-1427.
[http://dx.doi.org/10.1002/cbdv.201400094] [PMID: 25238082]
[115]
Thomas, G.A.; Rhodes, J.; Ingram, J.R. Mechanisms of disease: nicotine--a review of its actions in the context of gastrointestinal disease. Nat. Clin. Pract. Gastroenterol. Hepatol., 2005, 2(11), 536-544.
[http://dx.doi.org/10.1038/ncpgasthep0316] [PMID: 16355159]
[116]
Wallace, J.L. Prostaglandins, NSAIDs, and gastric mucosal protection: Why doesn’t the stomach digest itself? Physiol. Rev., 2008, 88(4), 1547-1565.
[http://dx.doi.org/10.1152/physrev.00004.2008] [PMID: 18923189]
[117]
Teng, L.; Ma, G.Z.; Li, L.; Ma, L.Y.; Xu, X.Q. Karatavicinol a, a new anti-ulcer sesquiterpene coumarin from Ferula sinkiangensis. Chem. Nat. Compd., 2013, 49, 606-609.
[http://dx.doi.org/10.1007/s10600-013-0690-1]
[118]
Repetto, M.G.; Llesuy, S.F. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz. J. Med. Biol. Res., 2002, 35(5), 523-534.
[http://dx.doi.org/10.1590/S0100-879X2002000500003] [PMID: 12011936]
[119]
Alqasoumi, S.; Al-Dosari, M.; Al-Howiriny, T.; Al-Yahya, M.; Al-Mofleh, I.; Rafatullah, S. Gastric antiulcer activity of a pungent spice Ferula assafoetida in rats. Farmacia, 2011, 59, 750-759.
[120]
Khazdair, M.R.; Boskabady, M.H. The relaxant effect of Ferula assafoetida on smooth muscles and the possible mechanisms. J. Herbmed. Pharmacol., 2015, 4, 219-223.
[121]
Kennedy, L.; Hodges, K.; Meng, F.; Alpini, G.; Francis, H. Histamine and histamine receptor regulation of gastrointestinal cancers. Transl. Gastrointest. Cancer, 2012, 1(3), 215-227.
[PMID: 24639917]
[122]
Dandagi, P.M.; Patil, M.B.; Mastiholimath, V.S.; Gadad, A.P.; Dhumansure, R.H. Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants. Indian J. Pharm. Sci., 2008, 70(2), 265-268.
[http://dx.doi.org/10.4103/0250-474X.41474] [PMID: 20046731]
[123]
Sharma, V.; Bisht, S.; Singh, M. Hepatoprotective and antidyslipidemic effect of in CCl induced Ferula asafetida. Asian J. Pharm. Pharmacol., 2018, 4, 61-65.
[http://dx.doi.org/10.31024/ajpp.2018.4.1.10]
[124]
Deniz, G.Y.; Laloglu, E.; Koc, K.; Geyikoglu, F. Hepatoprotective potential of Ferula communis extract for carbon tetrachloride induced hepatotoxicity and oxidative damage in rats. Biotech. Histochem., 2019, 94(5), 334-340.
[http://dx.doi.org/10.1080/10520295.2019.1566831] [PMID: 30712392]
[125]
Tayeboon, G.S.; Tavakoli, F.; Hassani, S.; Khanavi, M.; Sabzevari, O.; Ostad, S.N. Effects of Cymbopogon citratus and Ferula assa-foetida extracts on glutamateinduced neurotoxicity. In Vitro Cell. Dev. Biol. Anim., 2013, 49(9), 706-715.
[http://dx.doi.org/10.1007/s11626-013-9656-7] [PMID: 23949776]
[126]
Homayouni Moghadam, F.; Dehghan, M.; Zarepur, E.; Dehlavi, R.; Ghaseminia, F.; Ehsani, S.; Mohammadzadeh, G.; Barzegar, K. Oleo gum resin of Ferula assa-foetida L. ameliorates peripheral neuropathy in mice. J. Ethnopharmacol., 2014, 154(1), 183-189.
[http://dx.doi.org/10.1016/j.jep.2014.03.069] [PMID: 24709312]
[127]
Asma, K. Oleo gum resin of ferula asafetida: A traditional culinary spice in versatile pharmacological activities. Res. J. Recent Sci., 2015, 4, 16-22.
[128]
Cheng, C.Y.; Su, S.Y.; Tang, N.Y.; Ho, T.Y.; Lo, W.Y.; Hsieh, C.L. Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA(B1) receptor expression in transient focal cerebral ischemia in rats. Acta Pharmacol. Sin., 2010, 31(8), 889-899.
[http://dx.doi.org/10.1038/aps.2010.66] [PMID: 20644551]
[129]
Granger, R.E.; Campbell, E.L.; Johnston, G.A. (+)- And (-)-borneol: Efficacious positive modulators of GABA action at human recombinant α1β2γ2L GABA(A) receptors. Biochem. Pharmacol., 2005, 69(7), 1101-1111.
[http://dx.doi.org/10.1016/j.bcp.2005.01.002] [PMID: 15763546]
[130]
Toda, N.; Kishioka, S.; Hatano, Y.; Toda, H. Modulation of opioid actions by nitric oxide signalin. Anesthesiology, 2009, 110(1), 166-181.
[http://dx.doi.org/10.1097/ALN.0b013e31819146a9]
[131]
Sung, C.S.; Wen, Z.H.; Chang, W.K.; Chan, K.H.; Ho, S.T.; Tsai, S.K.; Chang, Y.C.; Wong, C.S. Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1β-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord. J. Neurochem., 2005, 94(3), 742-752.
[http://dx.doi.org/10.1111/j.1471-4159.2005.03226.x] [PMID: 16033422]
[132]
Koh, P.O. Ferulic acid modulates nitric oxide synthase expression in focal cerebral ischemia. Lab. Anim. Res., 2012, 28(4), 273-278.
[http://dx.doi.org/10.5625/lar.2012.28.4.273] [PMID: 23326288]
[133]
Song, J.J.; Cho, J.G.; Hwang, S.J.; Cho, C.G.; Park, S.W.; Chae, S.W. Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells. Acta Otolaryngol., 2008, 128(12), 1303-1307.
[http://dx.doi.org/10.1080/00016480801947082] [PMID: 18607954]
[134]
Ramezani, M.; Hosseinzadeh, H.; Mojtahedi, K. Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice. J. Ethnopharmacol., 2001, 77(1), 71-75.
[http://dx.doi.org/10.1016/S0378-8741(01)00263-X] [PMID: 11483380]
[135]
Jadidi, M.; Vafaie, A.; Miladi-Gorji, H.; Babaie-Saeidabadi, A. The effect of Ferula persica L extracts on symptoms of morphine withdrawal and sleeping time in mice. J. Res. Med. Sci., 2011, 34, 225-230.
[136]
Ye, B.; Wang, S.; Zhang, L. Studies on the detoxification effects and acute toxicity of a mixture of cis-sec-butyl-1-propoenyl disulphide and trans-sec-butyl-1-propoenyl disulphide isolated from crude essential oil of Ferula sinkiangensis K.M. Shen, a Chinese traditional herbal medicine. Nat. Prod. Res., 2011, 25(12), 1161-1170.
[http://dx.doi.org/10.1080/14786419.2010.550027] [PMID: 21740281]
[137]
Grutzendler, J.; Morris, J.C. Cholinesterase inhibitors for Alzheimer’s disease. Drugs, 2001, 61(1), 41-52.
[http://dx.doi.org/10.2165/00003495-200161010-00005] [PMID: 11217870]
[138]
Vijayalakshmi, S.A.; Adiga, S.; Bhat, P.; Chaturvedi, A.; Bairy, K.L.; Kamath, S. Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian J. Pharmacol., 2012, 44(1), 82-87.
[http://dx.doi.org/10.4103/0253-7613.91873] [PMID: 22345876]
[139]
Talesa, V.N. Acetylcholinesterase in Alzheimer’s disease. Mech. Ageing Dev., 2001, 122(16), 1961-1969.
[http://dx.doi.org/10.1016/S0047-6374(01)00309-8] [PMID: 11589914]
[140]
Bagheri, S.M.; Dashti-R, M.H. Influence of asafoetida on prevention and treatment of memory impairment induced by d-galactose and NaNO2 in mice. Am. J. Alzheimers Dis. Other Demen., 2015, 30(6), 607-612.
[http://dx.doi.org/10.1177/1533317515576388] [PMID: 25788433]
[141]
Adhami, H.R.; Scherer, U.; Kaehlig, H.; Hettich, T.; Schlotterbeck, G.; Reich, E.; Krenn, L. Combination of bioautography with HPTLC-MS/NMR: a fast identification of acetylcholinesterase inhibitors from galbanum (†). Phytochem. Anal., 2013, 24(4), 395-400.
[http://dx.doi.org/10.1002/pca.2422] [PMID: 23427054]
[142]
Adhami, H.R.; Fitz, V.; Lubich, A.; Kaehlig, H.; Zehl, M.; Krenn, L. Acetylcholinesterase inhibitors from galbanum, the oleo gum-resin of Ferula gummosa Boiss. Phytochem. Lett., 2014.
[http://dx.doi.org/10.1016/j.phytol.2014.08.023]
[143]
Kamal, M.; Jawaid, T. Herbal drugs in mirror of anxiety disorder-A review. Int. J. Biomed. Res., 2011, 2, 62-72.
[http://dx.doi.org/10.7439/ijbr.v2i1.81]
[144]
Alqasoumi, S. Anxiolytic effect of Ferula asafoetida L. in rodents. J. Pharmacog. Phytother., 2012, 4, 86-90.
[http://dx.doi.org/10.5897/JPP12.027]
[145]
Batra, S.; Kumar, A.; Sharma, A. Isolation, characterization and antianxiety activity of pentacosan-13-ol from Ferula sumbul hook. roots. J. Biologic. Active, 2018, 8, 171-179.
[http://dx.doi.org/10.1080/22311866.2018.1472037]
[146]
Kumar, T.B.; Reddy, V.J.; Rushendran, R.; Mamatha, T.; Roja, J.; Roopavani, T. Antidepressant activity of ethanolic extract of oleo gum resins of Ferula asafoetida Linn. J. Pre-Clin. Clin. Res., 2017, 11, 50-60.
[http://dx.doi.org/10.26444/jpccr/75721]
[147]
Mandegary, A.; Sayyah, M.; Heidari, M.R. Antinociceptive and anti-inflammatory activity of the seed and root extracts of Ferula gummosa Boiss in mice and rats. Daru, 2004, 12, 58-62.
[148]
Liapi, C.; Anifandis, G.; Chinou, I.; Kourounakis, A.P.; Theodosopoulos, S.; Galanopoulou, P. Antinociceptive properties of 1,8-Cineole and β-pinene, from the essential oil of Eucalyptus camaldulensis leaves, in rodents. Planta Med., 2007, 73(12), 1247-1254.
[http://dx.doi.org/10.1055/s-2007-990224] [PMID: 17893834]
[149]
Saghravanian, S.J.; Fereidoni, M.; Asadollahi, A. The effect of Ferula szowitsiana extract on chemical pain in male wistar rats. Arch. Biol. Sci., 2018, 70, 365-369.
[http://dx.doi.org/10.2298/ABS170326054S]
[150]
Bagheri, S.M.; Rezvani, M.E.; Vahidi, A.R.; Esmaili, M. Anticonvulsant effect of ferula assa-foetida oleo gum resin on chemical and amygdala-kindled rats. N. Am. J. Med. Sci., 2014, 6(8), 408-412.
[http://dx.doi.org/10.4103/1947-2714.139296] [PMID: 25210675]
[151]
Farzaei, M.H.; Farzaei, F.; Abdollahi, M.; Abbasabadi, Z.; Abdolghaffari, A.H.; Mehraban, B. A mechanistic review on medicinal plants used for rheumatoid arthritis in traditional Persian medicine. J. Pharm. Pharmacol., 2016, 68(10), 1233-1248.
[http://dx.doi.org/10.1111/jphp.12606] [PMID: 27417522]
[152]
Geroushi, A.; Auzi, A.A.; Elhwuegi, A.S.; Elzawam, F.; El-Sherif, A.; Nahar, L.; Sarker, S.D. Antinociceptive and anti-inflammatory activity of Ferula hermonis root oil in experimental animals. Lat. Am. J. Pharm., 2010, 29, 1436-1439.
[153]
Palumbo, C.; Ferretti, M.; Bertoni, L.; Cavani, F.; Resca, E.; Casolari, B.; Carnevale, G.; Zavatti, M.; Montanari, C.; Benelli, A.; Zanoli, P. Influence of ferutinin on bone metabolism in ovariectomized rats. I: Role in preventing osteoporosis. J. Bone Miner. Metab., 2009, 27(5), 538-545.
[http://dx.doi.org/10.1007/s00774-009-0070-x] [PMID: 19333679]
[154]
Znati, M.; Ben Jannet, H.; Cazaux, S.; Souchard, J.P.; Harzallah Skhiri, F.; Bouajila, J. Antioxidant, 5-lipoxygenase inhibitory and cytotoxic activities of compounds isolated from the Ferula lutea flowers. Molecules, 2014, 19(10), 16959-16975.
[http://dx.doi.org/10.3390/molecules191016959] [PMID: 25340301]
[155]
Znati, M.; Hichem, B.J.; Cazaux, S.; Bouajila, J. Chemical composition, biological and cytotoxic activities of plant extracts and compounds isolated from Ferula lutea. Molecules, 2014, 19(3), 2733-2747. b
[http://dx.doi.org/10.3390/molecules19032733] [PMID: 24577376]
[156]
Jemal, A.; Bray, F.; Center, MM.; Ferlay, J.; Ward, E. Forman, D Global cancer statistics. Cancer J. Clinic., 2011, 61, 69-90.
[157]
Okada, H.; Mak, T.W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat. Rev. Cancer, 2004, 4(8), 592-603.
[http://dx.doi.org/10.1038/nrc1412] [PMID: 15286739]
[158]
Keskin, O.; Bahar, I.; Jernigan, R.L.; Beutler, J.A.; Shoemaker, R.H.; Sausville, E.A.; Covell, D.G. Characterization of anticancer agents by their growth inhibitory activity and relationships to mechanism of action and structure. Anticancer Drug Des., 2000, 15(2), 79-98.
[PMID: 10901296]
[159]
Iranshahi, M.; Sahebkar, A.; Takasaki, M.; Konoshima, T.; Tokuda, H. Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo. Eur. J. Cancer Prev., 2009, 18(5), 412-415. b
[http://dx.doi.org/10.1097/CEJ.0b013e32832c389e] [PMID: 19531956]
[160]
Barthomeuf, C.; Lim, S.; Iranshahi, M.; Chollet, P. Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis. Phytomedicine, 2008, 15(1-2), 103-111.
[http://dx.doi.org/10.1016/j.phymed.2007.04.001] [PMID: 17689942]
[161]
Choi, Y.E.; Park, E. Ferulic acid in combination with PARP inhibitor sensitizes breast cancer cells as chemotherapeutic strategy. Biochem. Biophys. Res. Commun., 2015, 458(3), 520-524.
[http://dx.doi.org/10.1016/j.bbrc.2015.01.147] [PMID: 25677620]
[162]
Bagheri, S.M.; Abdian-Asl, A.; Moghadam, M.T.; Yadegari, M.; Mirjalili, A.; Zare-Mohazabieh, F.; Momeni, H. Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice. J. Ayurveda Integr. Med., 2017, 8(3), 152-158. a
[http://dx.doi.org/10.1016/j.jaim.2017.02.013] [PMID: 28690055]
[163]
Alkhatib, R.; Hennebelle, T.; Joha, S.; Idziorek, T.; Preudhomme, C.; Quesnel, B.; Sahpaz, S.; Bailleul, F. Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines. Phytochemistry, 2008, 69(17), 2979-2983.
[http://dx.doi.org/10.1016/j.phytochem.2008.09.019] [PMID: 18992904]
[164]
Lee, J.H.; Choi, S.; Lee, Y.; Lee, H.J.; Kim, K.H.; Ahn, K.S.; Bae, H.; Lee, H.J.; Lee, E.O.; Ahn, K.S.; Ryu, S.Y.; Lü, J. Kim. Herbal compound Farnesiferol c exerts antiangiogenic and antitumor activity and targets multiple aspects of vegfr1 (flt1) or vegfr2 (flk1) signaling cascades. Mol. Cancer Ther., 2010, 9(2), 389-399.
[http://dx.doi.org/10.1158/1535-7163.MCT-09-0775]
[165]
Matin, M.M.; Nakhaeizadeh, H.; Bahrami, A.R.; Iranshahi, M.; Arghiani, N.; Rassouli, F.B. Ferutinin, an apoptosis inducing terpenoid from Ferula ovina. Asian Pac. J. Cancer Prev., 2014, 15(5), 2123-2128.
[http://dx.doi.org/10.7314/APJCP.2014.15.5.2123] [PMID: 24716944]
[166]
Crompton, M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J., 1999, 341(Pt 2), 233-249.
[http://dx.doi.org/10.1042/bj3410233] [PMID: 10393078]
[167]
Soltani, S.; Amin, G.R.; Salehi-Sourmaghi, M.H.; Schneider, B.; Lorenz, S.; Iranshahi, M. Sulfur-containing compounds from the roots of Ferula latisecta and their cytotoxic activities. Fitoterapia, 2018, 124, 108-112.
[http://dx.doi.org/10.1016/j.fitote.2017.10.012] [PMID: 29066298]
[168]
Sevier, C.S.; Kaiser, C.A. Formation and transfer of disulphide bonds in living cells. Nat. Rev. Mol. Cell Biol., 2002, 3(11), 836-847.
[http://dx.doi.org/10.1038/nrm954] [PMID: 12415301]
[169]
Omar, S.H.; Al-Wabel, N.A. Organosulfur compounds and possible mechanism of garlic in cancer. Saudi Pharm. J., 2010, 18(1), 51-58.
[http://dx.doi.org/10.1016/j.jsps.2009.12.007] [PMID: 23960721]
[170]
Sharopov, F.S.; Khalifaev, P.D.; Satyal, P.; Sun, Y.; Safomuddin, A.; Musozoda, S.; Wink, M.; Setzer, W.N. The Chemical Composition and Biological Activity of the Essential Oil from the Underground Parts of Ferula tadshikorum (Apiaceae). Rec. Nat. Prod., 2019, 13, 18-23.
[http://dx.doi.org/10.25135/rnp.65.18.02.089]
[171]
Gudarzi, H.; Salimi, M.; Irian, S.; Amanzadeh, A.; Mostafapour-Kandelous, H.; Azadmanesh, K.; Salimi, M. Ethanolic extract of Ferula gummosa is cytotoxic against cancer cells by inducing apoptosis and cell cycle arrest, Natural Product Research; Formerly Natural Product Letters, 2014.
[172]
Mahaki, H.; Tanzadehpanah, H.; Abou-Zied, O.K.; Moghadam, N.H.; Bahmani, A.; Salehzadeh, S.; Dastan, D.; Saidijam, M. Cytotoxicity and antioxidant activity of Kamolonol acetate from Ferula pseudalliacea, and studying its interactions with calf thymus DNA (ct-DNA) and human serum albumin (HSA) by spectroscopic and molecular docking techniques. Process Biochem., 2019, 79, 203-213.
[http://dx.doi.org/10.1016/j.procbio.2018.12.004]
[173]
Iranshahy, M.; Iranshahi, M. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-a review. J. Ethnopharmacol., 2011, 134(1), 1-10.
[http://dx.doi.org/10.1016/j.jep.2010.11.067] [PMID: 21130854]
[174]
Saleem, M.; Alam, A.; Sultana, S. Asafoetida inhibits early events of carcinogenesis: A chemopreventive study. Life Sci., 2001, 68(16), 1913-1921.
[http://dx.doi.org/10.1016/S0024-3205(01)00977-8] [PMID: 11292069]
[175]
Mallikarjuna, G.U.; Dhanalakshmi, S.; Raisuddin, S.; Rao, A.R. Chemomodulatory influence of Ferula asafoetida on mammary epithelial differentiation, hepatic drug metabolizing enzymes, antioxidant profiles and N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats. Breast Cancer Res. Treat., 2003, 81(1), 1-10.
[http://dx.doi.org/10.1023/A:1025448620558] [PMID: 14531492]
[176]
Lahouel, M.; Zini, R.; Zellagui, A.; Rhouati, S.; Carrupt, P.A.; Morin, D. Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle. Biochem. Biophys. Res. Commun., 2007, 355(1), 252-257.
[http://dx.doi.org/10.1016/j.bbrc.2007.01.145] [PMID: 17292330]
[177]
Kochhar, K.P. Dietary spices in health and diseases: I. Indian J. Physiol. Pharmacol., 2008, 52(2), 106-122.
[PMID: 19130854]
[178]
Soltani, F.; Mosaffa, F.; Iranshahi, M.; Karimi, G.; Malekaneh, M.; Haghighi, F.; Behravan, J. Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stress. Cell Biol. Toxicol., 2009, 25(3), 291-296.
[http://dx.doi.org/10.1007/s10565-008-9083-9] [PMID: 18618275]
[179]
Miglietta, A.; Bocca, C.; Gadoni, E.; Gabriel, L.; Rampa, A.; Bisi, A.; Valenti, P.; Da Re, P. Interaction of geiparvarin and related compounds with purified microtubular protein. Anticancer Drug Des., 1996, 11(1), 35-48.
[PMID: 8639247]
[180]
Bocca, C.; Gabriel, L.; Bozzo, F.; Miglietta, A. Microtubuleinteracting activity and cytotoxicity of the prenylated coumarin ferulenol. Planta Med., 2002, 68(12), 1135-1137.
[http://dx.doi.org/10.1055/s-2002-36342] [PMID: 12494346]
[181]
Al-Jenoobi, F.I.; Al-Thukair, A.A.; Alam, M.A.; Abbas, F.A.; Al-Mohizea, A.M.; Alkharfy, K.M.; Al-Suwayeh, S.A. Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin. Saudi Pharm. J., 2014, 22(6), 564-569.
[http://dx.doi.org/10.1016/j.jsps.2014.03.004] [PMID: 25561870]
[182]
Saberi, E.A.; Ebrahimzadeh, A.; Ghanbari-Phiroozabadi, M.H. The antifungal effect of sodium hypochlorite in infected root canals with Candida albicans. Zahedan J. Res. Med. Sci., 2004, 6, 115-121.
[183]
Estrela, C.; Ribeiro, R.G.; Estrela, C.R.; Pécora, J.D.; Sousa-Neto, M.D. Antimicrobial effect of 2% sodium hypochlorite and 2% chlorhexidine tested by different methods. Braz. Dent. J., 2003, 14(1), 58-62.
[http://dx.doi.org/10.1590/S0103-64402003000100011] [PMID: 12656467]
[184]
Mozaffari, B.; Mansouri, S.H. Comparison of antibacterial and cytotoxic effects of Persica and chlorhexidine mouthwashes in vitro. J. Dairy Sci., 2006, 23, 494-509.
[185]
Nazemisalman, B.; Vahabi, S.; Yazdinejad, A.; Haghghi, F.; Jam, M.S.; Heydari, F. Comparison of antimicrobial effect of Ziziphora tenuior, Dracocephalum moldavica, Ferula gummosa, and Prangos ferulacea essential oil with chlorhexidine on Enterococcus faecalis: An in vitro study. Dent Res J (Isfahan), 2018, 15(2), 111-116.
[http://dx.doi.org/10.4103/1735-3327.226525] [PMID: 29576774]
[186]
Valle, M.G.; Appendino, G.; Nano, G.M.; Picci, V. Prenylated coumarins and sesquiterpenoids from Ferula communis. Phytochemistry, 1986, 26, 253-256.
[http://dx.doi.org/10.1016/S0031-9422(00)81522-8]
[187]
Bruneton, J.; Hatton, C.K.; Bruneton, A. Toxic plants: dangerous to humans and animals; Tec Doc, 1999.
[188]
Alzweiri, M.; Al-Shudeifat, M.; Al-Khaldi, K.; Al-Hiari, Y.; Afifi, F. Acetylated ferulenol-oxy-ferulenol as a proposed marker for fresh Ferula toxicity: A metabolomic approach. J. Liq. Chromatogr. Relat. Technol., 2015, 38, 283-288.
[http://dx.doi.org/10.1080/10826076.2014.908781]
[189]
Goudah, A.; Abdo-El-Sooud, K.; Yousef, M.A. Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents. Vet. World, 2015, 8(5), 584-589.
[http://dx.doi.org/10.14202/vetworld.2015.584-589] [PMID: 27047139]
[190]
Kelly, K.J.; Neu, J.; Camitta, B.M.; Honig, G.R. Methemoglobinemia in an infant treated with the folk remedy glycerited asafoetida. Pediatrics, 1984, 73(5), 717-719.
[PMID: 6609339]
[191]
Walia, K. Effect of asafoetida (7-hydroxycoumarin) on mouse spermatocytes. Cytologia (Tokyo), 1973, 38(4), 719-724.
[http://dx.doi.org/10.1508/cytologia.38.719] [PMID: 4783359]
[192]
Vahedi, M.M.; Mahdian, D.; Jafarian, A.H.; Iranshahi, M.; Esmaeilizadeh, M.; Ghorbani, A. Toxicity assessment of Ferula gummosa administration during pregnancy, lactation, and juvenile period in rat. Drug Chem. Toxicol., 2018, 41(2), 199-205.
[http://dx.doi.org/10.1080/01480545.2017.1337126] [PMID: 28678536]
[193]
Ghorbani, A.; Mohebbati, R.; Jafarian, A.H.; Vahedi, M.M.; Hosseini, S.M.; Soukhtanloo, M.; Sadeghnia, H.R. Azar Hosseini, Toxicity evaluation of hydroalcoholic extract of Ferula gummosa root. Regul. Toxicol. Pharmacol., 2016, 77, 35-41.
[http://dx.doi.org/10.1016/j.yrtph.2016.02.008] [PMID: 26893240]
[194]
Bagheri, S.M.; Sahebkar, A.; Gohari, A.R.; Saeidnia, S.; Malmir, M.; Iranshahi, M. Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species. Pharm. Biol., 2010, 48(3), 242-246.
[http://dx.doi.org/10.3109/13880200903081796] [PMID: 20645807]


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 20
ISSUE: 13
Year: 2020
Published on: 20 August, 2020
Page: [1233 - 1257]
Pages: 25
DOI: 10.2174/1389557520666200505125618
Price: $65

Article Metrics

PDF: 25
HTML: 2
EPUB: 1
PRC: 1