The Effect of Ginger-chamomile Sachet with Honey on Primary Dysmenorrhea and Associated Symptoms: A Randomized, Double-Blind, Controlled Trial

Author(s): Fatemeh Shabani, Aroona Chabra, Katayon Vakilian, Soodabeh Bioos, Mahbubeh Bozorgi, Mohammad Hosein Ayati, Fatemeh Nejatbakhsh*

Journal Name: Current Women`s Health Reviews

Volume 16 , Issue 4 , 2020

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Graphical Abstract:


Background: Dysmenorrhea is one of the most frequent pelvic pains among young women, impairing their quality of life.

Objective: This research aims to investigate the effect of ginger-chamomile herbs with honey in reducing dysmenorrhea pain, associated symptoms, and the extent of bleeding.

Methods: In this randomized clinical trial (IRCT No.: 2016100825031N5), 200 female students with primary dysmenorrhea, from Arak universities, were included and randomly divided into two groups. All the students were evaluated for one cycle without intervention, then group (A) received mefenamic acid (250 mg) and group (B) received ginger (1000 mg), chamomile (5000 mg), and one teaspoonful of honey for two days before and for the first three days of menstruation, three times a day, in two consecutive cycles. Pain severity, associated symptoms of dysmenorrhea, and bleeding were assessed using a visual analogue scale, Andersch-Milsom Verbal Scale, and Higham chart. Data were analyzed by descriptive and inferential statistical tests through SPSS21.

Results: The pain intensity in group B diminished significantly after the intervention in comparison to group A (p <0.05). The mean severity of dysmenorrhea accompanying symptoms decreased significantly in group B compared to group A (P=0.009). However, the mean quantity of bleeding significantly decreased in group A (P = 0.004), with no increase in the extent of bleeding in group B.

Conclusion: The present study indicated that the combination of the ginger-chamomile sachet with honey has the same effect as nonsteroidal anti-inflammatory drugs for pain mitigation, and the associated symptoms reduced better than mefenamic acid.

Keywords: Complementary medicine, dysmenorrhea, pain, ginger, honey, chamomile.

Latthe P, Latthe M, Say L. GA1/4lmezoglu M, Khan KS. WHO systematic review of prevalence of chronic pelvic pain: a neglected reproductive health morbidity. BMC Public Health 2006; 6(1): 177.
[] [PMID: 16824213]
Gebeyehu MB, Mekuria AB, Tefera YG, et al. Prevalence, impact, and management practice of dysmenorrhea among university of gondar students, northwestern ethiopia: A cross-sectional study. Int J Reprod Med 2017; 20173208276
[] [PMID: 28589173]
Kharaghani R, Damghanian M. The prevalence of dysmenorrhea in Iran: A systematic review and meta-analysis. Iran Red Crescent Med J 2017; 19(3)e40856
Ahuja A, Sharma MK, Singh A. Impact of dysmenorrhea on quality of life of adolescent girls of Chandigarh. J Child Adolesc Behav 2016; 4: 295.
Iacovides S, Avidon I, Bentley A, Baker FC. Reduced quality of life when experiencing menstrual pain in women with primary dysmenorrhea. Acta Obstet Gynecol Scand 2014; 93(2): 213-7.
[] [PMID: 24266425]
Berek J, Novak E. Berek and Novak’s gynecology. 15th ed. Philadelphia: Lippincott Williams &Wilkins 2016.
Zafari M, Behmanesh F, Agha Mohammadi A. Comparison of the effect of fish oil and ibuprofen on treatment of severe pain in primary dysmenorrhea. Caspian J Intern Med 2011; 2(3): 279-82.
[PMID: 24049587]
Lethaby A, Duckitt K, Farquhar C. Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding. Cochrane Database Syst Rev 2013; (1): CD000400
[] [PMID: 23440779]
Rahbar N, Asgharzadeh N, Ghorbani R. Effect of omega-3 fatty acids on intensity of primary dysmenorrhea. Int J Gynaecol Obstet 2012; 117(1): 45-7.
[] [PMID: 22261128]
Mirabi P, Alamolhoda SH, Esmaeilzadeh S, Mojab F. Effect of medicinal herbs on primary dysmenorrhoea-a systematic review. Iran J Pharm Res 2014; 13(3): 757-67.
[PMID: 25276177]
Saei Gharenaz M, Ozgoli G. Effect of medicinal plants in the treatment of primary dysmenorrhea in Iran: a review article. IJOGI 2015; 18(160): 14-31.
Babazadeh R, Keramat A. Premenstrual syndrome and complementary medicine in Iran: a systematic review. Feyz 2011; 15(2): 174-87.
Karimian Z, Sadat Z, Abedzadeh M, et al. Comparison the effect of mefenamic acid and matricaria chamomilla on primary dysmenorrhea in Kashan Medical University students. J Ardabil Univ Med Sci 2013; 13(4): 413-20.
Jenabi E, Ebrahimzadeh S. Chamomile tea for relief of primary dysmenorrhea. IJOGI 2010; 13(1): 39-42.
Davdabady Farahani M, Vakilian K, Seyyedzadeh Aghdam N, Ranjbaran M. The effect of valerian and ginger on dysmenorrhea-A randomized clinical trial. IJWHR 2020; 8: 101-5.
Daily JW, Zhang X, Kim DS, Park S. Efficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysis of randomized clinical trials. Pain Med 2015; 16(12): 2243-55.
[] [PMID: 26177393]
Kitzes G, Schuette H, Elvehjem C. The B vitamins in honey. J Nutr 1943; 26(3): 241-50.
Dunford C, Cooper R, Molan P, White R. The use of honey in wound management. Nurs Stand 2000; 15(11): 63-8.
[] [PMID: 11971572]
Al-Waili N, Salom K, Al-Ghamdi AA. Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. ScientificWorldJournal 2011; 11: 766-87.
[] [PMID: 21479349]
Amiri Farahani AL, Hasanpoor-Azghdy SB, Kasraei H, Heidari T. Comparison of the effect of honey and mefenamic acid on the severity of pain in women with primary dysmenorrhea. Arch Gynecol Obstet 2017; 296(2): 277-83.
[] [PMID: 28623433]
Mirbagher Ajorpaz N, Hafezi M, Salehi S, Tayebi A, Shenasa F, Zantabchi S. Comparing the effect of pure and impure honey on severity of pain, amount of bleeding, and duration and interval of menstrual cycles in female students with primary dysmenorrhea. Evid Based Care J 2012; 2(1): 23-33.
Shabani F, Zareian MA. Evaluation of the possibility of synergism of medicinal effects of chamomile and ginger on pain and symptoms of primary dysmenorrhea A randomized controlled trial cmja 2020; 9(4): 3852-67.
Amiri S, Sharafzadeh S. Essential oil components of German chamomile cultivated in Firoozabad, Iran. Orient J Chem 2014; 30(1): 365-7.
Kamaliroosta Z, Kamaliroosta L, Elhamirad A. Isolation and identification of ginger essential oil. J Food Biosci Technol 2013; 3: 73-80.
Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol 2008; 46(2): 409-20.
[] [PMID: 17950516]
Terry R, Posadzki P, Watson LK, Ernst E. The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med 2011; 12(12): 1808-18.
[] [PMID: 22054010]
Iwasaki Y, Morita A, Iwasawa T, et al. A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1. Nutr Neurosci 2006; 9(3-4): 169-78.
[] [PMID: 17176640]
Kavuluru VKSKP. A study to assess the effectiveness of ginger preparation on dysmenorrhea among adolescent girls. IJAR 2017; 3(3): 22-5.
Khalesi ZB, Beiranvand SP, Bokaie M. Efficacy of Chamomile in the Treatment of Premenstrual Syndrome: A Systematic Review. J Pharmacopuncture 2019; 22(4): 204-9.
[] [PMID: 31970017]
Rajabzaheh F, Fazljou SM, Khodaie L, Abbasalizadeh S, Sahebi L. Effects of hot temperament herbs on primary dysmenorrhea: a systematic review. World Fam Med J 2018; 16(3): 257-63.
Forster HB, Niklas H, Lutz S. Antispasmodic effects of some medicinal plants. Planta Med 1980; 40(4): 309-19.
[] [PMID: 7220648]
Srivastava JK, Pandey M, Gupta S. Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sci 2009; 85(19-20): 663-9.
[] [PMID: 19788894]
McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother Res 2006; 20(8): 619-33.
[] [PMID: 16767798]
Al-Waili NS, Boni NS. Natural honey lowers plasma prostaglandin concentrations in normal individuals. J Med Food 2003; 6(2): 129-33.
[] [PMID: 12935324]
Markelov V, Trushin M. Bee venom therapy and low dose naltrexone for treatment of multiple sclerosis. Nepal J Neurosci 2006; 3(2): 71-7.
Al-Waili NS. Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals. J Med Food 2003; 6(2): 135-40.
[] [PMID: 12935325]
Shirvani MA, Motahari-Tabari N, Alipour A. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet 2015; 291(6): 1277-81.
[] [PMID: 25399316]
Al-Waili NS, Saloom KS, Al-Waili TN, Al-Waili AN. The safety and efficacy of a mixture of honey, olive oil, and beeswax for the management of hemorrhoids and anal fissure: a pilot study. ScientificWorldJournal 2006; 6: 1998-2005.
[] [PMID: 17369999]
Ryan JL, Heckler CE, Roscoe JA, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer 2012; 20(7): 1479-89.
[] [PMID: 21818642]
Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, Leeprakobboon K, Leelasettagool C. The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol 2006; 194(1): 95-9.
[] [PMID: 16389016]
Crotteau CA, Wright ST, Eglash A. Clinical inquiries. What is the best treatment for infants with colic? J Fam Pract 2006; 55(7): 634-6.
[PMID: 16822454]
Sakai H, Misawa M. Effect of sodium azulene sulfonate on capsaicin-induced pharyngitis in rats. Basic Clin Pharmacol Toxicol 2005; 96(1): 54-9.
[] [PMID: 15667596]
Pena D, Montes de Oca N, Rojas S. Anti-inflammatory and anti-diarrheic activity of Isocarpha cubana Blake. Pharmacologyonline 2006; 3: 744-9.
Merfort I, Heilmann J, Hagedorn-Leweke U, Lippold BC. In vivo skin penetration studies of camomile flavones. Pharmazie 1994; 49(7): 509-11.
[PMID: 8073060]
Amsterdam JD, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. Altern Ther Health Med 2012; 18(5): 44-9.
[PMID: 22894890]

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Article Details

Year: 2020
Published on: 08 September, 2020
Page: [348 - 358]
Pages: 11
DOI: 10.2174/1573404816999200505105057
Price: $65

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