Immunotherapy: A Potential Approach to Targeting Cancer Stem Cells

Author(s): Wenjun Wang, Ling Bai, Dongsheng Xu, Wei Li, Jiuwei Cui*

Journal Name: Current Cancer Drug Targets

Volume 21 , Issue 2 , 2021


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Abstract:

Tumor recurrence and drug resistance are two of the key factors affecting the prognosis of cancer patients. Cancer stem cells (CSCs) are a group of cells with infinite proliferation potential which are not sensitive to traditional therapies, including radio- and chemotherapy. These CSCs are considered to be central to tumor recurrence and the development of drug resistance. In addition, CSCs are important targets in cancer immunotherapy because of their expression of novel tumorassociated antigens, which result from mutations in cancer cells over the course of treatment. Emerging immunotherapies, including cancer vaccines, checkpoint blockade therapies, and transferred immune cell therapies, have all been shown to be more effective when they selectively target CSCs. Such therapies may also provide novel additions to the current therapeutic milieu and may offer new therapeutic combinations for treatment. This review summarizes the relationships between various immunotherapies and CSCs and provides novel insights into potential therapeutic applications for these approaches in the future.

Keywords: Immunotherapy, cancer stem cell, therapeutic application, clinical, target, mechanism.

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Article Details

VOLUME: 21
ISSUE: 2
Year: 2021
Published on: 25 March, 2021
Page: [117 - 131]
Pages: 15
DOI: 10.2174/1568009620666200504111914
Price: $65

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