Title:Lead Anti-Obesity Compounds from Nature
VOLUME: 20 ISSUE: 10
Author(s):Vinesh Dahiya, Neeru Vasudeva*, Sunil Sharma, Ashok Kumar and David Rowley
Affiliation:Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, Internal Medicine, Kansas University Medical Centre, Kansas City, Kansas, Pharmacognosy Department, University of Rhode Island, Kingston, Rhode Island
Keywords:Obesity, natural products, plants, phytochemicals, anti-obesity compounds, anti-lipolytic compounds, marine
sources.
Abstract:
Background: Obesity has become a global issue, leading to increased risk of metabolic
syndrome, which encompasses diabetes, cardiovascular disease, stroke, hypertension, and certain cancers.
However, obesity is difficult to control through diet and exercise alone, as they are difficult to
implement.
Objective: The objective of this review is to elucidate the active constituents that can be obtained from
various natural sources that act as anti-obesity agents. Due to the global rise in the prevalence of obesity,
an urgent need to prevent and control it has arisen.
Methods: For this review, we compiled information about natural anti-obesity products through an
electronic search of the articles available via PubMed, Scopus, and other internet sources for the period
1975-2019 and included our own research. We analyzed and organized data on various natural products
in popular use in addition to relevant pharmacognostic and biological studies. The products’
mechanisms of action were also investigated.
Conclusion: Consumption of diets that include high amounts of active anti-obesity natural compounds
is a promising strategy for the suppression of lipid accumulation and adipogenesis in obese individuals.
