The application of medicinal plants has captured the interest of researchers in recent times
due to their potent therapeutic properties and a better safety profile. The prominent role of herbal products
in treating and preventing multiple diseases dates back to ancient history and most of the modern
drugs today originated from their significant sources owing to their ability to control multiple targets
via different signalling pathways. Among them, flavonoids consist of a large group of polyphenols,
which are well known for their various therapeutic benefits. Rutin is considered one of the attractive
phytochemicals and important flavonoids in the pharmaceutical industry due to its diverse pharmacological
activities via various underlying molecular mechanisms. It is usually prescribed for various
disease conditions such as varicosities, haemorrhoids and internal haemorrhage. In this review, we
have discussed and highlighted the different molecular mechanisms attributed to the various pharmacological
activities of rutin, such as antioxidant, anti-inflammatory, anticancer, anti-allergic and antidiabetic.
This review will be beneficial to herbal, biological and molecular scientists in understanding
the pharmacological relevance of rutin at the molecular level.