In recent years, hybrid systems are gaining considerable attention owing to their various biological applications
in drug development. Generally, hybrid molecules are constructed from different molecular entities to
generate a new functional molecule with improved biological activities. There already exist a large number of
naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature
through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) Carbon-
Carbon bond formation between different components derived through different biosynthetic pathways. Multicomponent
reactions are a great way to generate efficient libraries of hybrid compounds with high diversity.
Throughout the scientific history, the most common factors developing technologies are less energy consumption
and avoiding the use of hazardous reagents. In this case, microwave energy plays a vital role in chemical transformations
since it involves two very essential criteria of synthesis, minimizing energy consumption required for
heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis
of steroidal and non-steroidal hybrid molecules and the use of multicomponent reactions.
Keywords: Microwave energy, hybrid molecule, carbon-carbon bond formation, Ugi-4CR, steroids, hazardous reagents.
Rights & PermissionsPrintExport