An Overview on Steroids and Microwave Energy in Multi-Component Reactions towards the Synthesis of Novel Hybrid Molecules

Author(s): Preetismita Borah*, Vhatkar Dattatraya Shivling, Bimal Krishna Banik, Biswa Mohan Sahoo

Journal Name: Current Organic Synthesis

Volume 17 , Issue 8 , 2020

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Graphical Abstract:


In recent years, hybrid systems are gaining considerable attention owing to their various biological applications in drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exist a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) Carbon- Carbon bond formation between different components derived through different biosynthetic pathways. Multicomponent reactions are a great way to generate efficient libraries of hybrid compounds with high diversity. Throughout the scientific history, the most common factors developing technologies are less energy consumption and avoiding the use of hazardous reagents. In this case, microwave energy plays a vital role in chemical transformations since it involves two very essential criteria of synthesis, minimizing energy consumption required for heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis of steroidal and non-steroidal hybrid molecules and the use of multicomponent reactions.

Keywords: Microwave energy, hybrid molecule, carbon-carbon bond formation, Ugi-4CR, steroids, hazardous reagents.

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Article Details

Year: 2020
Published on: 17 November, 2020
Page: [594 - 609]
Pages: 16
DOI: 10.2174/1570179417666200503050106
Price: $65

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